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Journal of Medicinal Chemistry|March 12, 2014
Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 3. Structure-activity relationships within the aryl carbinol region of the N-arylsulfonamido-N'-arylpiperazine seriesNobuko Nishimura, Mark H Norman, Longbin Liu, et al.Journal of Medicinal Chemistry|July 26, 2014
Discovery of clinical candidate 1-(4-(3-(4-(1H-benzo[d]imidazole-2-carbonyl)phenoxy)pyrazin-2-yl)piperidin-1-yl)ethanone (AMG 579), a potent, selective, and efficacious inhibitor of phosphodiesterase 10A (PDE10A)Essa Hu, Ning Chen, Matthew P Bourbeau, et al.Bioorganic & Medicinal Chemistry|December 3, 2014
Synthesis and preliminary biological evaluation of potent and selective 2-(3-alkoxy-1-azetidinyl) quinolines as novel PDE10A inhibitors with improved solubilityRobert M Rzasa, Michael J Frohn, Kristin L Andrews, et al.The Journal of Pharmacology and Experimental Therapeutics|December 16, 2014
AMG 580: a novel small molecule phosphodiesterase 10A (PDE10A) positron emission tomography tracerHang Chen, Dianna Lester-Zeiner, Jianxia Shi, et al.Journal of Medicinal Chemistry|January 11, 2014
Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 2. Leveraging structure-based drug design to identify analogues with improved pharmacokinetic profilesDavid J St Jean, Kate S Ashton, Michael D Bartberger, et al.Critical Care Explorations|November 28, 2022
Outcomes of Early Versus Late Tracheostomy in Patients With COVID-19: A Multinational Cohort StudyConstance S Harrell Shreckengost, Jorge Esteban Foianini, Karen Milenka Moron Encinas, et al.Pageof 7