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Proceedings of the National Academy of Sciences of the United States of America|February 28, 2002
Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrateWilliam P Esler, W Taylor Kimberly, Beth L Ostaszewski, et al.The Journal of Biological Chemistry|July 15, 2003
Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrinMatthew J LaVoie, Patrick C Fraering, Beth L Ostaszewski, et al.Biochemistry|January 8, 2003
Notch and the amyloid precursor protein are cleaved by similar gamma-secretase(s)W Taylor Kimberly, William P Esler, Wenjuan Ye, et al.Journal of Neuroscience Research|September 18, 2016
Cell-based high-throughput screening identifies galactocerebrosidase enhancers as potential small-molecule therapies for Krabbe's diseaseDae Song Jang, Wenjuan Ye, Tian Guimei, et al.Journal of Neurochemistry|November 8, 2007
Rapid purification of active gamma-secretase, an intramembrane protease implicated in Alzheimer's diseaseMatthias Cacquevel, Lorene Aeschbach, Pamela Osenkowski, et al.Journal of Molecular Biology|November 18, 2008
Cryoelectron microscopy structure of purified gamma-secretase at 12 A resolutionPamela Osenkowski, Hua Li, Wenjuan Ye, et al.Bioorganic & Medicinal Chemistry Letters|March 26, 2016
Part 1: Notch-sparing γ-secretase inhibitors: The identification of novel naphthyl and benzofuranyl amide analogsDai Lu, Han-Xun Wei, Jing Zhang, et al.Oncogene|May 3, 2018
A modified gene trap approach for improved high-throughput cancer drug discoveryShelli M Morris, Andrew J Mhyre, Savanna S Carmack, et al.Bioorganic & Medicinal Chemistry Letters|March 30, 2016
Part 2. Notch-sparing γ-secretase inhibitors: The study of novel γ-amino naphthyl alcoholsHan-Xun Wei, Dai Lu, Vivien Sun, et al.Journal of Ethnopharmacology|March 29, 2026
Xiaoyaosan Ameliorates Stress-Induced MASH via Modulating IL-1R1/RXRα-Mediated Liver-Brain CrosstalkYi Zhang, Xiaoru Luo, Shuya Wu, et al.Pageof 5