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Plos One|September 24, 2015
Mitotic Checkpoint Kinase Mps1 Has a Role in Normal Physiology which Impacts Clinical UtilityRicardo Martinez, Alessandra Blasina, Jill F Hallin, et al.
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research|November 5, 2020
Development of Highly Optimized Antibody-Drug Conjugates against CD33 and CD123 for Acute Myeloid LeukemiaYoon-Chi Han, Jennifer Kahler, Nicole Piché-Nicholas, et al.
Proceedings of the National Academy of Sciences of the United States of America|March 4, 2015
PF-06463922 is a potent and selective next-generation ROS1/ALK inhibitor capable of blocking crizotinib-resistant ROS1 mutationsHelen Y Zou, Qiuhua Li, Lars D Engstrom, et al.
Toxicological Sciences : an Official Journal of the Society of Toxicology|May 25, 2023
Use of the dTAG system in vivo to degrade CDK2 and CDK5 in adult mice and explore potential safety liabilitiesPaul Yenerall, Tae Sung, Kiran Palyada, et al.
Journal of Medicinal Chemistry|September 23, 2011
Discovery of aryloxy tetramethylcyclobutanes as novel androgen receptor antagonistsChuangxing Guo, Angelica Linton, Susan Kephart, et al.
Cancer Cell|July 7, 2015
PF-06463922, an ALK/ROS1 Inhibitor, Overcomes Resistance to First and Second Generation ALK Inhibitors in Preclinical ModelsHelen Y Zou, Luc Friboulet, David P Kodack, et al.
Journal of Medicinal Chemistry|August 12, 2016
Design and Synthesis of Pyridone-Containing 3,4-Dihydroisoquinoline-1(2H)-ones as a Novel Class of Enhancer of Zeste Homolog 2 (EZH2) InhibitorsPei-Pei Kung, Eugene Rui, Simon Bergqvist, et al.
Journal of Medicinal Chemistry|December 7, 2017
Optimization of Orally Bioavailable Enhancer of Zeste Homolog 2 (EZH2) Inhibitors Using Ligand and Property-Based Design Strategies: Identification of Development Candidate (R)-5,8-Dichloro-7-(methoxy(oxetan-3-yl)methyl)-2-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3,4-dihydroisoquinolin-1(2H)-one (PF-06821497)Pei-Pei Kung, Patrick Bingham, Alexei Brooun, et al.
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