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Bioorganic & Medicinal Chemistry|July 20, 2011
The effect of sulfonate leaving groups on the hypoxia-selective toxicity of nitro analogs of the duocarmycinsAmir Ashoorzadeh, Graham J Atwell, Frederik B Pruijn, et al.The Journal of Biological Chemistry|November 8, 2013
Zinc finger nuclease knock-out of NADPH:cytochrome P450 oxidoreductase (POR) in human tumor cell lines demonstrates that hypoxia-activated prodrugs differ in POR dependenceJiechuang Su, Yongchuan Gu, Frederik B Pruijn, et al.Frontiers in Oncology|October 11, 2013
The Role of Bystander Effects in the Antitumor Activity of the Hypoxia-Activated Prodrug PR-104Annika Foehrenbacher, Kashyap Patel, Maria R Abbattista, et al.Cancer Chemotherapy and Pharmacology|August 5, 2010
A combined pharmacokinetic model for the hypoxia-targeted prodrug PR-104A in humans, dogs, rats and mice predicts species differences in clearance and toxicityKashyap Patel, Steve S F Choy, Kevin O Hicks, et al.Journal of Medicinal Chemistry|December 10, 2009
4-Pyridylanilinothiazoles that selectively target von Hippel-Lindau deficient renal cell carcinoma cells by inducing autophagic cell deathMichael P Hay, Sandra Turcotte, Jack U Flanagan, et al.Biochemical Pharmacology|April 10, 2018
Drug-DNA adducts as biomarkers for metabolic activation of the nitro-aromatic nitrogen mustard prodrug PR-104AAlessia Stornetta, Kai-Cheng Kieren Deng, Sara Danielli, et al.Chemical Research in Toxicology|April 22, 2003
Effect of nitroreduction on the alkylating reactivity and cytotoxicity of the 2,4-dinitrobenzamide-5-aziridine CB 1954 and the corresponding nitrogen mustard SN 23862: distinct mechanisms of bioreductive activationNuala A Helsby, S James Wheeler, Frederik B Pruijn, et al.Molecular Cancer Therapeutics|June 11, 2009
Roles of DNA repair and reductase activity in the cytotoxicity of the hypoxia-activated dinitrobenzamide mustard PR-104AYongchuan Gu, Adam V Patterson, Graham J Atwell, et al.Plos One|June 27, 2013
Zinc finger nuclease mediated knockout of ADP-dependent glucokinase in cancer cell lines: effects on cell survival and mitochondrial oxidative metabolismSusan Richter, Shona Morrison, Tim Connor, et al.Cancers|December 16, 2020
Patient-Derived Xenograft and Organoid Models for Precision Medicine Targeting of the Tumour Microenvironment in Head and Neck CancerTet Woo Lee, Amy Lai, Julia K Harms, et al.Pageof 16