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Cancer Research|October 27, 2018
Temozolomide Induces Senescence and Repression of DNA Repair Pathways in Glioblastoma Cells via Activation of ATR-CHK1, p21, and NF-κBDorthe Aasland, Laura Götzinger, Laura Hauck, et al.
Cell Biology and Toxicology|May 24, 2022
The epigenetic modifier HDAC2 and the checkpoint kinase ATM determine the responses of microsatellite instable colorectal cancer cells to 5-fluorouracilNicole Kiweler, Helena Schwarz, Alexandra Nguyen, et al.
Cancer Letters|May 14, 2018
Multiple DNA damage-dependent and DNA damage-independent stress responses define the outcome of ATR/Chk1 targeting in medulloblastoma cellsKatharina Krüger, Katharina Geist, Fabian Stuhldreier, et al.
International Journal of Molecular Sciences|July 9, 2020
In Vitro Assessment of the Genotoxic Hazard of Novel Hydroxamic Acid- and Benzamide-Type Histone Deacetylase Inhibitors (HDACi)Annabelle Friedrich, Ann-Sophie Assmann, Lena Schumacher, et al.
Molecular Cell|December 28, 2022
Cryo-EM structure of the Mre11-Rad50-Nbs1 complex reveals the molecular mechanism of scaffolding functionsMatthias Rotheneder, Kristina Stakyte, Erik van de Logt, et al.
Biomolecules|March 28, 2026
Hypomorphic Protein Expression of DNA Polymerase Beta in PolβL301R-V303R/L301R-V303R Knock-In Transgenic Mice Does Not Impact Global DNA Methylation Levels in the MidbrainBryce Jacobs, Dan Ivanov, Ivana Barraza, et al.
DNA Repair|June 19, 2024
Oncometabolite 2-hydroxyglutarate suppresses basal protein levels of DNA polymerase beta that enhances alkylating agent and PARG inhibition induced cytotoxicityKate M Saville, Rasha Q Al-Rahahleh, Aisha H Siddiqui, et al.
NAR Cancer|January 2, 2026
Replication-associated base excision repair/single-strand break repair regulates PARG inhibitor response via the PRMT1/PRMT5/ATR axisMd Ibrahim, Wynand P Roos, Jacob C Schwartz, et al.
Nucleic Acids Research|July 4, 2025
TRIP12's role in the governance of DNA polymerase β involvement in DNA damage response and repairBurcu Inanc, Qingming Fang, Wynand P Roos, et al.
Biorxiv : the Preprint Server for Biology|November 24, 2025
AAV Kills Dividing Cells by Depleting PARP1 and Other DNA Damage Response ProteinsSasha Friese, Junjie Zai, Grace Luzbetak, et al.
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