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Plos One|May 20, 2024
Discovery of allosteric regulators with clinical potential to stabilize alpha-L-iduronidase in mucopolysaccharidosis type IElena Cubero, Ana Ruano, Aida Delgado, et al.Journal of Medicinal Chemistry|September 23, 2024
Use of the Novel Site-Directed Enzyme Enhancement Therapy (SEE-Tx) Drug Discovery Platform to Identify Pharmacological Chaperones for Glutaric Acidemia Type 1Madalena Barroso, Alexandra Puchwein-Schwepcke, Lars Buettner, et al.International Journal of Molecular Sciences|May 4, 2026
Development of Small-Molecule Allosteric Modulators of Beta-Galactosidase (β-Gal) for the Treatment of GM1 Gangliosidosis and Morquio BNatàlia Pérez-Carmona, Elena Cubero, Ana Ruano, et al.Angewandte Chemie (International Ed. in English)|November 21, 2025
Water Networks as Hydrophobic Recognition Motifs in ProteinsSerena G Piticchio, Miriam Martínez-Cartró, Salvatore Scaffidi, et al.Journal of Medicinal Chemistry|June 25, 2005
Novel, potent small-molecule inhibitors of the molecular chaperone Hsp90 discovered through structure-based designBrian W Dymock, Xavier Barril, Paul A Brough, et al.Journal of Medicinal Chemistry|December 13, 2021
Discovery of Novel BRD4 Ligand Scaffolds by Automated Navigation of the Fragment Chemical SpaceSerena G Piticchio, Míriam Martínez-Cartró, Salvatore Scaffidi, et al.Bioorganic & Medicinal Chemistry Letters|February 17, 2006
4-Amino derivatives of the Hsp90 inhibitor CCT018159Xavier Barril, Mandy C Beswick, Adam Collier, et al.Chemmedchem|November 11, 2015
Combined Use of Oligopeptides, Fragment Libraries, and Natural Compounds: A Comprehensive Approach To Sample the Druggability of Vascular Endothelial Growth FactorNúria Bayó-Puxan, Ricard Rodríguez-Mias, Michael Goldflam, et al.Bioorganic & Medicinal Chemistry Letters|June 29, 2010
4-(3-Trifluoromethylphenyl)-pyrimidine-2-carbonitrile as cathepsin S inhibitors: N3, not N1 is critically importantJiaqiang Cai, Xavier Fradera, Mario van Zeeland, et al.ACS Medicinal Chemistry Letters|December 18, 2020
Optimization of Versatile Oxindoles as Selective PI3Kδ InhibitorsJoey L Methot, Abdelghani Achab, Matthew Christopher, et al.Pageof 13