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Journal of Medicinal Chemistry|October 20, 2025
Structure- and Privileged Fragment-Based Iterative Optimization: Discovery of 2,4-Disubstituted-6-aminopyrimidines as Novel HIV-1 NNRTIs with Potent Activity against Drug-Resistant Strains and Favorable Safety ProfilesXiangkai Ji, Xiangyi Jiang, Heng Gao, et al.
Bioorganic Chemistry|August 31, 2025
Design, synthesis, and biological evaluation of dual-site HIV-1 inhibitors simultaneously targeting the NNRTI binding pocket and an adjacent site with favorable resistance profilesXiangkai Ji, Xiangyi Jiang, Xing Huang, et al.
Journal of Medicinal Chemistry|September 17, 2025
Exploring the HIV-1 Reverse Transcriptase p51/p66 Interface: Structure-Based Design and Optimization of Novel 2,4,6-Trisubstituted Pyrimidines as Potent NNRTIs with Improved Resistance ProfilesXiangkai Ji, Xiangyi Jiang, Zhen Gao, et al.
Molecules (Basel, Switzerland)|September 23, 2022
Design, Synthesis, and Evaluation of a Set of Carboxylic Acid and Phosphate Prodrugs Derived from HBV Capsid Protein Allosteric Modulator NVR 3-778Xiangkai Ji, Xiangyi Jiang, Chisa Kobayashi, et al.
European Journal of Medicinal Chemistry|October 6, 2024
Identification of novel diarylpyrimidine derivatives as potent HIV-1 non-nucleoside reverse transcriptase inhibitors against wild-type and K103N mutant virusesXiangyi Jiang, Waleed A Zalloum, Zhen Gao, et al.
Bioorganic & Medicinal Chemistry|September 25, 2021
Design, synthesis, and antiviral activity of phenylalanine derivatives as HIV-1 capsid inhibitorsJing Li, Xiangyi Jiang, Alexej Dick, et al.
European Journal of Medicinal Chemistry|July 2, 2023
Discovery of novel diarypyrimidine derivatives bearing six-membered non-aromatic heterocycles as potent HIV-1 NNRTIs with improved anti-resistance and drug-like profilesXiangyi Jiang, Boshi Huang, Waleed A Zalloum, et al.
Bioorganic Chemistry|January 9, 2026
Discovery of novel diarylpyrimidine derivatives as HIV-1 non-nucleoside reverse transcriptase inhibitors: Design, synthesis and biological activity evaluationHao Lin, Zhongxia Zhou, Lin Zheng, et al.
Molecules (Basel, Switzerland)|September 23, 2022
Design, Synthesis and Structure-Activity Relationships of Phenylalanine-Containing Peptidomimetics as Novel HIV-1 Capsid Binders Based on Ugi Four-Component ReactionXiangkai Ji, Jing Li, Prem Prakash Sharma, et al.
Journal of Medical Virology|April 5, 2024
Discovery of low-molecular-weight phenylalanine derivatives as novel HIV capsid modulators with improved antiretroviral activity and metabolic stabilityXiangyi Jiang, Zhen Gao, Prem Prakash Sharma, et al.
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