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Bioorganic & Medicinal Chemistry Letters|July 6, 2010
Spiroindane based amides as potent and selective MC4R agonists for the treatment of obesityShuwen He, Zhixiong Ye, Peter H Dobbelaar, et al.Journal of Medicinal Chemistry|July 25, 2025
Discovery of Gut-Targeted GPR40 Agonist K-757 and GPR119 Agonist K-833, a Combination Treatment for Metabolic DisordersChristopher R Moyes, Shuwen He, Simon Mathieu, et al.Bioorganic & Medicinal Chemistry Letters|March 29, 2011
Discovery of a piperazine urea based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor partial agonistQingmei Hong, Raman K Bakshi, Brenda L Palucki, et al.Bioorganic & Medicinal Chemistry Letters|October 12, 2010
Discovery of highly potent and efficacious MC4R agonists with spiroindane N-Me-1,2,4-triazole privileged structures for the treatment of obesityShuwen He, Zhixiong Ye, Peter H Dobbelaar, et al.Cell Metabolism|January 26, 2010
Regulation of energy homeostasis by bombesin receptor subtype-3: selective receptor agonists for the treatment of obesityXiao-Ming Guan, Howard Chen, Peter H Dobbelaar, et al.Bioorganic & Medicinal Chemistry Letters|March 12, 2010
Synthesis and SAR of derivatives based on 2-biarylethylimidazole as bombesin receptor subtype-3 (BRS-3) agonists for the treatment of obesityJian Liu, Shuwen He, Tianying Jian, et al.Bioorganic & Medicinal Chemistry Letters|March 9, 2010
Discovery of a spiroindane based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor agonistShuwen He, Zhixiong Ye, Peter H Dobbelaar, et al.Bioorganic & Medicinal Chemistry Letters|April 7, 2019
Accelerating the discovery of DGAT1 inhibitors through the application of parallel medicinal chemistry (PMC)Yang Yu, Zhicai Wu, Zhi-Cai Shi, et al.Bioorganic & Medicinal Chemistry Letters|March 31, 2019
Benzimidazole-based DGAT1 inhibitors with a [3.1.0] bicyclohexane carboxylic acid moietyShuwen He, Zhong Lai, Qingmei Hong, et al.Bioorganic & Medicinal Chemistry Letters|July 6, 2010
Optimization of privileged structures for selective and potent melanocortin subtype-4 receptor ligandsQingmei Hong, Raman K Bakshi, James Dellureficio, et al.Pageof 21