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European Journal of Medicinal Chemistry|September 25, 2020
Targeting dual tolerant regions of binding pocket: Discovery of novel morpholine-substituted diarylpyrimidines as potent HIV-1 NNRTIs with significantly improved water solubilityZhao Wang, Dongwei Kang, Da Feng, et al.
European Journal of Medicinal Chemistry|February 10, 2021
Identification of novel potent HIV-1 inhibitors by exploiting the tolerant regions of the NNRTIs binding pocketYanying Sun, Dongwei Kang, Feng Da, et al.
European Journal of Medicinal Chemistry|August 3, 2023
5-Cyano substituted diarylpyridines as potent HIV-1 NNRTIs: Rational design, synthesis, and activity evaluationHao Song, Yu Xia, Tao Zhang, et al.
European Journal of Medicinal Chemistry|March 21, 2016
Design, synthesis and evaluation of novel HIV-1 NNRTIs with dual structural conformations targeting the entrance channel of the NNRTI binding pocketQing Meng, Xuwang Chen, Dongwei Kang, et al.
RSC Medicinal Chemistry|November 4, 2024
Miniaturized click chemistry and direct screening facilitate the discovery of triazole piperazine SARS-CoV-2 Mpro inhibitors with improved metabolic stabilityShenghua Gao, Letian Song, Bing Ye, et al.
Bioorganic & Medicinal Chemistry Letters|March 15, 2018
First discovery of a potential carbonate prodrug of NNRTI drug candidate RDEA427 with submicromolar inhibitory activity against HIV-1 K103N/Y181C double mutant strainBoshi Huang, Xinhao Liu, Ye Tian, et al.
European Journal of Medicinal Chemistry|March 4, 2017
Discovery of uracil-bearing DAPYs derivatives as novel HIV-1 NNRTIs via crystallographic overlay-based molecular hybridizationHeng Zhang, Ye Tian, Dongwei Kang, et al.
Molecules (Basel, Switzerland)|October 26, 2007
Synthesis of novel derivatives of 4-amino-3-(2-furyl)-5-mercapto-1,2,4-triazole as potential HIV-1 NNRTIsJingde Wu, Xinyong Liu, Xianchao Cheng, et al.
Chemical Biology & Drug Design|March 29, 2014
Synthesis and anti-HIV activity of 4-(naphthalen-1-yl)-1,2,5-thiadiazol-3-hydroxyl derivativesDiwakar Rai, Wenmin Chen, Peng Zhan, et al.
European Journal of Medicinal Chemistry|August 5, 2014
Fused heterocycles bearing bridgehead nitrogen as potent HIV-1 NNRTIs. Part 2: discovery of novel [1,2,4]Triazolo[1,5-a]pyrimidines using a structure-guided core-refining approachLiu Wang, Ye Tian, Wenmin Chen, et al.
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