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Bioorganic Chemistry|January 9, 2026
Discovery of novel diarylpyrimidine derivatives as HIV-1 non-nucleoside reverse transcriptase inhibitors: Design, synthesis and biological activity evaluationHao Lin, Zhongxia Zhou, Lin Zheng, et al.Journal of Medicinal Chemistry|March 18, 2021
2,4,5-Trisubstituted Pyrimidines as Potent HIV-1 NNRTIs: Rational Design, Synthesis, Activity Evaluation, and Crystallographic StudiesDongwei Kang, Francesc X Ruiz, Yanying Sun, et al.European Journal of Medicinal Chemistry|December 19, 2020
Design, synthesis, and evaluation of "dual-site"-binding diarylpyrimidines targeting both NNIBP and the NNRTI adjacent site of the HIV-1 reverse transcriptaseDa Feng, Xiaofang Zuo, Lanlan Jing, et al.RSC Medicinal Chemistry|October 20, 2023
Identification of novel 1,2,3-triazole isatin derivatives as potent SARS-CoV-2 3CLpro inhibitors via click-chemistry-based rapid screeningXiangyi Jiang, Jing Li, Antonio Viayna, et al.International Journal of Molecular Sciences|January 21, 2023
Covalently Targeted Highly Conserved Tyr318 to Improve the Drug Resistance Profiles of HIV-1 NNRTIs: A Proof-of-Concept StudyZhenzhen Zhou, Bairu Meng, Jiaqi An, et al.Chemical Biology & Drug Design|August 7, 2018
Design, synthesis, and antiviral evaluation of novel hydrazone-substituted thiophene[3,2-d]pyrimidine derivatives as potent human immunodeficiency virus-1 inhibitorsZhao Wang, Dongwei Kang, Meng Chen, et al.Bioorganic & Medicinal Chemistry Letters|July 8, 2020
Discovery of potential dual-target prodrugs of HIV-1 reverse transcriptase and nucleocapsid protein 7Songkai Sun, Boshi Huang, Zhuo Li, et al.Molecules (Basel, Switzerland)|October 14, 2022
Discovery of Novel Boron-Containing N-Substituted Oseltamivir Derivatives as Anti-Influenza A Virus Agents for Overcoming N1-H274Y Oseltamivir-ResistantRuifang Jia, Jiwei Zhang, Jian Zhang, et al.Molecules (Basel, Switzerland)|December 11, 2022
Discovery and Mechanistic Investigation of Piperazinone Phenylalanine Derivatives with Terminal Indole or Benzene Ring as Novel HIV-1 Capsid ModulatorsShujing Xu, Lin Sun, Waleed A Zalloum, et al.European Journal of Medicinal Chemistry|February 25, 2020
Discovery of novel "Dual-site" binding oseltamivir derivatives as potent influenza virus neuraminidase inhibitorsWei Ai, Jian Zhang, Waleed A Zalloum, et al.Pageof 40