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Journal of Medicinal Chemistry|November 22, 2023
Design, Synthesis, and Biological Evaluation of Trisubstituted Piperazine Derivatives as Noncovalent Severe Acute Respiratory Syndrome Coronavirus 2 Main Protease Inhibitors with Improved Antiviral Activity and Favorable DruggabilityShenghua Gao, Letian Song, Katharina Sylvester, et al.Journal of Medicinal Chemistry|November 10, 2025
Multisite Occupancy and Multidimensional Optimization: Design and Evaluation of Piperazine-Thioureidobenzamide Derivatives as Potent HBV Capsid Assembly ModulatorsMinghui Liang, Yutong Dou, Jian Zhang, et al.Journal of Medicinal Chemistry|October 17, 2024
"Pseudosubstrate Envelope"/Free Energy Perturbation-Guided Design and Mechanistic Investigations of Benzothiazole HIV Capsid Modulators with High Ligand EfficiencyShujing Xu, Shuo Wang, Yang Zhou, et al.Journal of Medicinal Chemistry|November 4, 2021
Identification of C5-NH2 Modified Oseltamivir Derivatives as Novel Influenza Neuraminidase Inhibitors with Highly Improved Antiviral Activities and Favorable DruggabilityHan Ju, N Arul Murugan, Lingxin Hou, et al.Molecules (Basel, Switzerland)|January 8, 2023
Identification of Polyphenol Derivatives as Novel SARS-CoV-2 and DENV Non-Nucleoside RdRp InhibitorsShenghua Gao, Letian Song, Hongtao Xu, et al.Journal of Medicinal Chemistry|August 8, 2022
Iterative Optimization and Structure-Activity Relationship Studies of Oseltamivir Amino Derivatives as Potent and Selective Neuraminidase Inhibitors via Targeting 150-CavityHan Ju, Lingxin Hou, Fabao Zhao, et al.Chemical Biology & Drug Design|December 19, 2018
Design, synthesis, and biologic evaluation of novel galloyl derivatives as HIV-1 RNase H inhibitorsPing Gao, Xueshun Wang, Lin Sun, et al.Journal of Medicinal Chemistry|February 6, 2019
Exploiting the Tolerant Region I of the Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI) Binding Pocket: Discovery of Potent Diarylpyrimidine-Typed HIV-1 NNRTIs against Wild-Type and E138K Mutant Virus with Significantly Improved Water Solubility and Favorable Safety ProfilesBoshi Huang, Wenmin Chen, Tong Zhao, et al.Journal of Medical Virology|August 10, 2022
Discovery of novel 1,2,4-triazole phenylalanine derivatives targeting an unexplored region within the interprotomer pocket of the HIV capsid proteinXiangyi Jiang, Prem Prakash Sharma, Brijesh Rathi, et al.Bioorganic Chemistry|October 20, 2022
Design, synthesis, and biological evaluation of novel sulfamoylbenzamide derivatives as HBV capsid assembly modulatorsShuo Wang, Yujie Ren, Qilan Li, et al.Pageof 40