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European Journal of Medicinal Chemistry|March 4, 2025
Design, synthesis, and biological evaluation of novel BTK-targeting proteolysis targeting chimeras (PROTACs) with enhanced pharmacokinetic propertiesYing Lin, Jing Liu, Xinjian Tian, et al.Journal of Medicinal Chemistry|February 4, 2022
Discovery of Potent, Selective, and In Vivo Efficacious AKT Kinase Protein Degraders via Structure-Activity Relationship StudiesXufen Yu, Jia Xu, Yudao Shen, et al.Journal of Medicinal Chemistry|January 3, 2020
Discovery of Potent and Selective Epidermal Growth Factor Receptor (EGFR) Bifunctional Small-Molecule DegradersMeng Cheng, Xufen Yu, Kaylene Lu, et al.Journal of Medicinal Chemistry|December 2, 2021
Design, Synthesis, and Evaluation of Potent, Selective, and Bioavailable AKT Kinase DegradersXufen Yu, Jia Xu, Ling Xie, et al.Journal of Medicinal Chemistry|May 13, 2026
Targeted Degradation of Prolyl Hydroxylase Domain Enzyme 1 (PHD1) as a Novel Therapeutic Strategy for Acetaminophen-Induced Acute Liver InjuryHuahua Su, Yuting Li, Ting Xie, et al.Oncogene|February 6, 2023
Dissecting and targeting noncanonical functions of EZH2 in multiple myeloma via an EZH2 degraderXufen Yu, Jun Wang, Weida Gong, et al.ACS Pharmacology & Translational Science|July 15, 2022
Targeting Triple-Negative Breast Cancer by a Novel Proteolysis Targeting Chimera Degrader of Enhancer of Zeste Homolog 2Brandon Dale, Chris Anderson, Kwang-Su Park, et al.Nature Biotechnology|November 13, 2019
Dose-dependent activation of gene expression is achieved using CRISPR and small molecules that recruit endogenous chromatin machineryAnna M Chiarella, Kyle V Butler, Berkley E Gryder, et al.Journal of Medicinal Chemistry|August 14, 2020
Discovery of First-in-Class Protein Arginine Methyltransferase 5 (PRMT5) DegradersYudao Shen, Guozhen Gao, Xufen Yu, et al.ACS Chemical Neuroscience|August 8, 2019
Designing Functionally Selective Noncatechol Dopamine D<sub>1</sub> Receptor Agonists with Potent In Vivo Antiparkinsonian ActivityMichael L Martini, Caroline Ray, Xufen Yu, et al.Pageof 6