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Molecular & Cellular Proteomics : MCP|June 6, 2025
Soluble VCAM-1 May Serve as a Pharmacodynamic CSF Marker to Monitor BACE2 Activity in Non-Human PrimatesSarah K Tschirner, Y Joy Yu Zuchero, Jennifer A Getz, et al.
Bioanalysis|April 21, 2016
Characterization of a sensitive mouse Aβ40 PD biomarker assay for Alzheimer's disease drug development in wild-type miceYanmei Lu, Kwame Hoyte, William H Montgomery, et al.
The Journal of Biological Chemistry|January 13, 2017
Effector-attenuating Substitutions That Maintain Antibody Stability and Reduce Toxicity in MiceMegan Lo, Hok Seon Kim, Raymond K Tong, et al.
Neuron|December 22, 2015
Discovery of Novel Blood-Brain Barrier Targets to Enhance Brain Uptake of Therapeutic AntibodiesY Joy Yu Zuchero, Xiaocheng Chen, Nga Bien-Ly, et al.
Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism|August 16, 2025
Transferrin receptor-mediated transport at the blood-brain barrier is elevated during early development and maintained across aging and in an Alzheimer's mouse modelVanessa O Torres, Michelle E Pizzo, Darren Chan, et al.
Nature Communications|February 20, 2025
Fc-engineered large molecules targeting blood-brain barrier transferrin receptor and CD98hc have distinct central nervous system and peripheral biodistributionNathalie Khoury, Michelle E Pizzo, Claire B Discenza, et al.
Science Translational Medicine|May 29, 2020
Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeysMihalis S Kariolis, Robert C Wells, Jennifer A Getz, et al.
Cell Reports|July 24, 2025
Dual targeting of transferrin receptor and CD98hc enhances brain exposure of large moleculesRobert C Wells, Padma Akkapeddi, Darren Chan, et al.
Nature Communications|August 19, 2023
CD98hc is a target for brain delivery of biotherapeuticsKylie S Chew, Robert C Wells, Arash Moshkforoush, et al.
Science (New York, N.Y.)|August 7, 2025
Transferrin receptor-targeted anti-amyloid antibody enhances brain delivery and mitigates ARIAMichelle E Pizzo, Edward D Plowey, Nathalie Khoury, et al.
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