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Drug Metabolism and Disposition: the Biological Fate of Chemicals
|
July 5, 2023
A 20-Year Research Overview: Quantitative Prediction of Hepatic Clearance Using the In Vitro-In Vivo Extrapolation Approach Based on Physiologically Based Pharmacokinetic Modeling and Extended Clearance Concept
Yuichi Sugiyama, Yasunori Aoki
CPT: Pharmacometrics & Systems Pharmacology
|
October 19, 2023
Cluster Gauss-Newton method for a quick approximation of profile likelihood: With application to physiologically-based pharmacokinetic models
Yasunori Aoki, Yuichi Sugiyama
Frontiers in Pharmacology
|
August 9, 2024
When to consider intra-target microdosing: physiologically based pharmacokinetic modeling approach to quantitatively identify key factors for observing target engagement
Yasunori Aoki, Malcom Rowland, Yuichi Sugiyama
The AAPS Journal
|
February 10, 2016
Preconditioning of Nonlinear Mixed Effects Models for Stabilisation of Variance-Covariance Matrix Computations
Yasunori Aoki, Rikard Nordgren, Andrew C Hooker
The AAPS Journal
|
December 9, 2025
Simultaneous Target-Mediated Drug Disposition-Pharmacodynamic (TMDD-PD) Modeling of Finasteride and Dutasteride: Impact of Target Binding and Turnover on Non-linear Pharmacokinetics
Yuki Iwaki, Wooin Lee, Yasunori Aoki, et al.
Drug Safety
|
February 3, 2020
Disproportionality Analysis for Pharmacovigilance Signal Detection in Small Databases or Subsets: Recommendations for Limiting False-Positive Associations
Ola Caster, Yasunori Aoki, Lucie M Gattepaille, et al.
Computer Methods and Programs in Biomedicine
|
March 23, 2016
PopED lite: An optimal design software for preclinical pharmacokinetic and pharmacodynamic studies
Yasunori Aoki, Monika Sundqvist, Andrew C Hooker, et al.
Journal of Pharmacokinetics and Pharmacodynamics
|
November 6, 2017
Model selection and averaging of nonlinear mixed-effect models for robust phase III dose selection
Yasunori Aoki, Daniel Röshammar, Bengt Hamrén, et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals
|
February 9, 2021
Revisiting Nonlinear Bosentan Pharmacokinetics by Physiologically Based Pharmacokinetic Modeling: Target Binding, Albeit Not a Major Contributor to Nonlinearity, Can Offer Prediction of Target Occupancy
Satoshi Koyama, Kota Toshimoto, Wooin Lee, et al.
Clinical and Translational Science
|
November 27, 2024
Trends of in vitro pharmacological potency and in vivo pharmacokinetics parameters of modern drugs: Can the therapeutic/subtherapeutic dose be estimated from in vitro K<sub>i</sub> and pharmacokinetic parameters?
Toshiaki Tsuchitani, Motohiro Kato, Atsuko Tomaru, et al.
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of 6
Search research articles
Search
Showing results (1-10 of 56) with videos related to
Sort By:
Page
of 6
Drug Metabolism and Disposition: the Biological Fate of Chemicals
|
July 5, 2023
A 20-Year Research Overview: Quantitative Prediction of Hepatic Clearance Using the In Vitro-In Vivo Extrapolation Approach Based on Physiologically Based Pharmacokinetic Modeling and Extended Clearance Concept
Yuichi Sugiyama, Yasunori Aoki
CPT: Pharmacometrics & Systems Pharmacology
|
October 19, 2023
Cluster Gauss-Newton method for a quick approximation of profile likelihood: With application to physiologically-based pharmacokinetic models
Yasunori Aoki, Yuichi Sugiyama
Frontiers in Pharmacology
|
August 9, 2024
When to consider intra-target microdosing: physiologically based pharmacokinetic modeling approach to quantitatively identify key factors for observing target engagement
Yasunori Aoki, Malcom Rowland, Yuichi Sugiyama
The AAPS Journal
|
February 10, 2016
Preconditioning of Nonlinear Mixed Effects Models for Stabilisation of Variance-Covariance Matrix Computations
Yasunori Aoki, Rikard Nordgren, Andrew C Hooker
The AAPS Journal
|
December 9, 2025
Simultaneous Target-Mediated Drug Disposition-Pharmacodynamic (TMDD-PD) Modeling of Finasteride and Dutasteride: Impact of Target Binding and Turnover on Non-linear Pharmacokinetics
Yuki Iwaki, Wooin Lee, Yasunori Aoki, et al.
Drug Safety
|
February 3, 2020
Disproportionality Analysis for Pharmacovigilance Signal Detection in Small Databases or Subsets: Recommendations for Limiting False-Positive Associations
Ola Caster, Yasunori Aoki, Lucie M Gattepaille, et al.
Computer Methods and Programs in Biomedicine
|
March 23, 2016
PopED lite: An optimal design software for preclinical pharmacokinetic and pharmacodynamic studies
Yasunori Aoki, Monika Sundqvist, Andrew C Hooker, et al.
Journal of Pharmacokinetics and Pharmacodynamics
|
November 6, 2017
Model selection and averaging of nonlinear mixed-effect models for robust phase III dose selection
Yasunori Aoki, Daniel Röshammar, Bengt Hamrén, et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals
|
February 9, 2021
Revisiting Nonlinear Bosentan Pharmacokinetics by Physiologically Based Pharmacokinetic Modeling: Target Binding, Albeit Not a Major Contributor to Nonlinearity, Can Offer Prediction of Target Occupancy
Satoshi Koyama, Kota Toshimoto, Wooin Lee, et al.
Clinical and Translational Science
|
November 27, 2024
Trends of in vitro pharmacological potency and in vivo pharmacokinetics parameters of modern drugs: Can the therapeutic/subtherapeutic dose be estimated from in vitro K<sub>i</sub> and pharmacokinetic parameters?
Toshiaki Tsuchitani, Motohiro Kato, Atsuko Tomaru, et al.
Page
of 6