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Chemical & Pharmaceutical Bulletin|March 2, 2018
Fragment-Based Discovery of Pyrimido[1,2-b]indazole PDE10A InhibitorsAyaka Chino, Ryushi Seo, Yasushi Amano, et al.
Bioorganic & Medicinal Chemistry|August 27, 2018
Discovery and structural characterization of peficitinib (ASP015K) as a novel and potent JAK inhibitorHisao Hamaguchi, Yasushi Amano, Ayako Moritomo, et al.
Bioorganic & Medicinal Chemistry|May 12, 2015
Addressing phototoxicity observed in a novel series of biaryl derivatives: discovery of potent, selective and orally active phosphodiesterase 10A inhibitor ASP9436Wataru Hamaguchi, Naoyuki Masuda, Satoshi Miyamoto, et al.
Bioorganic & Medicinal Chemistry|July 15, 2019
Synthesis, SAR study, and biological evaluation of novel 2,3-dihydro-1H-imidazo[1,2-a]benzimidazole derivatives as phosphodiesterase 10A inhibitorsAyaka Chino, Shugo Honda, Masataka Morita, et al.
Bioorganic & Medicinal Chemistry|December 18, 2014
Synthesis, SAR study, and biological evaluation of novel quinoline derivatives as phosphodiesterase 10A inhibitors with reduced CYP3A4 inhibitionWataru Hamaguchi, Naoyuki Masuda, Satoshi Miyamoto, et al.
Bioorganic & Medicinal Chemistry|August 4, 2022
Discovery and biological evaluation of 1-{2,7-diazaspiro[3.5]nonan-2-yl}prop-2-en-1-one derivatives as covalent inhibitors of KRAS G12C with favorable metabolic stability and anti-tumor activityTomoyoshi Imaizumi, Michinori Akaiwa, Tomoaki Abe, et al.
ACS Omega|July 31, 2023
Discovery of a Hidden Trypanosoma cruzi Spermidine Synthase Binding Site and Inhibitors through In Silico, In Vitro, and X-ray CrystallographyRyunosuke Yoshino, Nobuaki Yasuo, Yohsuke Hagiwara, et al.
Scientific Reports|July 29, 2017
In silico, in vitro, X-ray crystallography, and integrated strategies for discovering spermidine synthase inhibitors for Chagas diseaseRyunosuke Yoshino, Nobuaki Yasuo, Yohsuke Hagiwara, et al.
Bioorganic & Medicinal Chemistry|January 4, 2024
Discovery of ASP6918, a KRAS G12C inhibitor: Synthesis and structure-activity relationships of 1-{2,7-diazaspiro[3.5]non-2-yl}prop-2-en-1-one derivatives as covalent inhibitors with good potency and oral activity for the treatment of solid tumorsTomoyoshi Imaizumi, Itsuro Shimada, Yoshiki Satake, et al.
Bioorganic & Medicinal Chemistry|April 13, 2020
Structure-based drug design of 1,3,5-triazine and pyrimidine derivatives as novel FGFR3 inhibitors with high selectivity over VEGFR2Ikumi Kuriwaki, Minoru Kameda, Hiroyuki Hisamichi, et al.
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