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Antimicrobial Agents and Chemotherapy|September 22, 2020
A Cyclic Phosphoramidate Prodrug of 2'-Deoxy-2'-Fluoro-2'-C-Methylguanosine for the Treatment of Dengue Virus InfectionRatna Karuna, Fumiaki Yokokawa, Keshi Wang, et al.Journal of Medicinal Chemistry|January 7, 2026
Discovery of IID432 for Chagas Disease: A Cyanotriazole Inhibitor of Trypanosoma cruzi Topoisomerase II Achieves Sterile Cure After Short-Term Treatment in a Chronic Infection ModelOlivier René, Manuel Saldivia, Maxime Dauphinais, et al.Journal of Medicinal Chemistry|August 22, 2022
Discovery of Novel Quinoline-Based Proteasome Inhibitors for Human African Trypanosomiasis (HAT)Dennis C Koester, Vanessa M Marx, Sarah Williams, et al.Proceedings of the National Academy of Sciences of the United States of America|November 18, 2009
An adenosine nucleoside inhibitor of dengue virusZheng Yin, Yen-Liang Chen, Wouter Schul, et al.Science Translational Medicine|February 4, 2021
NITD-688, a pan-serotype inhibitor of the dengue virus NS4B protein, shows favorable pharmacokinetics and efficacy in preclinical animal modelsStephanie A Moquin, Oliver Simon, Ratna Karuna, et al.Science (New York, N.Y.)|June 29, 2023
Cyanotriazoles are selective topoisomerase II poisons that rapidly cure trypanosome infectionsSrinivasa P S Rao, Matthew K Gould, Jonas Noeske, et al.Journal of Medicinal Chemistry|July 16, 2020
Discovery and Characterization of Clinical Candidate LXE408 as a Kinetoplastid-Selective Proteasome Inhibitor for the Treatment of LeishmaniasesAdvait Nagle, Agnes Biggart, Celine Be, et al.Journal of Medicinal Chemistry|March 1, 2022
Discovery and Preclinical Pharmacology of INE963, a Potent and Fast-Acting Blood-Stage Antimalarial with a High Barrier to Resistance and Potential for Single-Dose Cures in Uncomplicated MalariaBenjamin R Taft, Fumiaki Yokokawa, Tom Kirrane, et al.Pageof 5