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Cell|December 3, 2015
High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer LiabilitiesTraver Hart, Megha Chandrashekhar, Michael Aregger, et al.
Communications Chemistry|June 27, 2026
Structure and mechanism of inhibition of lysine demethylase 2A (KDM2A) by compound 183cPavel Mader, Linshan Liu, Frédéric Vallée, et al.
Molecular Cell|July 21, 2023
Genome-scale mapping of DNA damage suppressors through phenotypic CRISPR-Cas9 screensYichao Zhao, Daniel Tabet, Diana Rubio Contreras, et al.
Nature|November 22, 2005
A phosphatase complex that dephosphorylates gammaH2AX regulates DNA damage checkpoint recoveryMichael-Christopher Keogh, Jung-Ae Kim, Michael Downey, et al.
Elife|June 28, 2021
Resistance to different anthracycline chemotherapeutics elicits distinct and actionable primary metabolic dependencies in breast cancerShawn McGuirk, Yannick Audet-Delage, Matthew G Annis, et al.
Nature Communications|December 5, 2020
A substrate binding model for the KEOPS tRNA modifying complexJonah Beenstock, Samara Mishelle Ona, Jennifer Porat, et al.
Molecular Cell|October 28, 2008
Atomic structure of the KEOPS complex: an ancient protein kinase-containing molecular machineDaniel Y L Mao, Dante Neculai, Michael Downey, et al.
ACS Medicinal Chemistry Letters|February 18, 2026
Design of a Targeted Covalent Probe to Interrogate the DNA Polymerase Activity of PolθMonica Bubenik, Pavel Mader, Stephen Orlicky, et al.
Proceedings of the National Academy of Sciences of the United States of America|October 22, 2008
Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotesScott J Dixon, Yaroslav Fedyshyn, Judice L Y Koh, et al.
Cancer Research|November 15, 2019
CD44 Promotes PD-L1 Expression and Its Tumor-Intrinsic Function in Breast and Lung CancersTim Kong, Ryuhjin Ahn, Kangning Yang, et al.
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