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Biorxiv : the Preprint Server for Biology|March 31, 2025
The EC2 domains of tetraspanins CD9, CD81, and CD151 bind to the allosteric site of integrins (site 2) and activate integrins αvβ3, α5β1 and α4β1 in a biphasic mannerYoko K Takada, Yoshikazu TakadaInternational Journal of Molecular Sciences|September 13, 2025
Ivermectin Binds to the Allosteric Site (Site 2) and Inhibits Allosteric Integrin Activation by TNF and Other Pro-Inflammatory CytokinesYoko K Takada, Yoshikazu TakadaCells|September 28, 2023
Virtual Screening of Protein Data Bank via Docking Simulation Identified the Role of Integrins in Growth Factor Signaling, the Allosteric Activation of Integrins, and P-Selectin as a New Integrin LigandYoshikazu Takada, Masaaki Fujita, Yoko K TakadaPlos One|May 3, 2014
The chemokine fractalkine can activate integrins without CX3CR1 through direct binding to a ligand-binding site distinct from the classical RGD-binding siteMasaaki Fujita, Yoko K Takada, Yoshikazu TakadaJournal of Immunology (Baltimore, Md. : 1950)|November 6, 2012
Integrins αvβ3 and α4β1 act as coreceptors for fractalkine, and the integrin-binding defective mutant of fractalkine is an antagonist of CX3CR1Masaaki Fujita, Yoko K Takada, Yoshikazu TakadaCytokine & Growth Factor Reviews|February 14, 2017
Crosstalk between insulin-like growth factor (IGF) receptor and integrins through direct integrin binding to IGF1Yoshikazu Takada, Yoko K Takada, Masaaki FujitaThe Journal of Biological Chemistry|December 18, 2012
Insulin-like growth factor (IGF) signaling requires αvβ3-IGF1-IGF type 1 receptor (IGF1R) ternary complex formation in anchorage independence, and the complex formation does not require IGF1R and Src activationMasaaki Fujita, Yoko K Takada, Yoshikazu TakadaCells|October 14, 2022
Pro-Inflammatory Chemokines CCL5, CXCL12, and CX3CL1 Bind to and Activate Platelet Integrin αIIbβ3 in an Allosteric MannerYoko K Takada, Masaaki Fujita, Yoshikazu TakadaCells|August 11, 2023
CD40L Activates Platelet Integrin αIIbβ3 by Binding to the Allosteric Site (Site 2) in a KGD-Independent Manner and HIGM1 Mutations Are Clustered in the Integrin-Binding Sites of CD40LYoko K Takada, Michiko Shimoda, Yoshikazu TakadaPageof 4