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Journal of Medicinal Chemistry|April 4, 2023
Discovery of the First Raptor (Regulatory-Associated Protein of mTOR) Inhibitor as a New Type of Antiadipogenic AgentXue-Long Yan, Yue-Hua Pan, Run-Zhu Fan, et al.Signal Transduction and Targeted Therapy|February 17, 2025
Glibenclamide targets MDH2 to relieve aging phenotypes through metabolism-regulated epigenetic modificationZhifan Mao, Wenwen Liu, Rong Zou, et al.Human Molecular Genetics|August 21, 2009
Leucine-Rich Repeat Kinase 2 interacts with Parkin, DJ-1 and PINK-1 in a Drosophila melanogaster model of Parkinson's diseaseKaterina Venderova, Ghassan Kabbach, Elizabeth Abdel-Messih, et al.Journal of Medicinal Chemistry|July 12, 2024
Development of Novel N-Acylhydrazone Derivatives with High Anti-obesity Activity and Improved Safety by Exploring the Pharmaceutical Properties of Aldehyde GroupZhi Jiang, Yu-Tao Hu, Shi-Yao Guo, et al.Diabetes, Obesity & Metabolism|November 12, 2024
L-aspartate ameliorates diet-induced obesity by increasing adipocyte energy expenditureShi-Yao Guo, Yu-Tao Hu, Yong Rao, et al.Journal of Medicinal Chemistry|September 2, 2022
Discovery of a Novel G-Quadruplex and Histone Deacetylase (HDAC) Dual-Targeting Agent for the Treatment of Triple-Negative Breast CancerXin-Chen Jiang, Fang-Hai Tu, Li-Yuan Wei, et al.Hepatology (Baltimore, Md.)|April 1, 2026
HSP72 interacts with PRDX6 to deubiquitinate mitochondrial PINK1, activating mitophagy to treat MASLDYong Rao, Rui Su, Wen-Jie Cao, et al.Journal of Medicinal Chemistry|July 23, 2020
Design, Synthesis, and Evaluation of New Quinazolinone Derivatives that Inhibit Bloom Syndrome Protein (BLM) Helicase, Trigger DNA Damage at the Telomere Region, and Synergize with PARP InhibitorsChen-Xi Wang, Zi-Lin Zhang, Qi-Kun Yin, et al.Journal of Medicinal Chemistry|May 30, 2023
Design and Synthesis of Bouchardatine Derivatives as a Novel AMP-Activated Protein Kinase Activator for the Treatment of Colorectal CancerYao-Hao Xu, Yu-Tao Hu, Shu-Min Xu, et al.British Journal of Pharmacology|November 16, 2021
A novel HSF1 activator ameliorates non-alcoholic steatohepatitis by stimulating mitochondrial adaptive oxidationYong Rao, Chan Li, Yu-Tao Hu, et al.Pageof 13