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Molecular Therapy. Nucleic Acids|November 19, 2014
Shielding of Lipid Nanoparticles for siRNA Delivery: Impact on Physicochemical Properties, Cytokine Induction, and EfficacyVarun Kumar, June Qin, Yongfeng Jiang, et al.
Biochemical and Biophysical Research Communications|January 12, 2002
Cloning and expression of the rat vacuole membrane protein 1 (VMP1), a new gene activated in pancreas with acute pancreatitis, which promotes vacuole formationNelson J Dusetti, Yongfeng Jiang, Maria I Vaccaro, et al.
Nucleic Acids Research|March 15, 2020
Chimeric siRNAs with chemically modified pentofuranose and hexopyranose nucleotides: altritol-nucleotide (ANA) containing GalNAc-siRNA conjugates: in vitro and in vivo RNAi activity and resistance to 5'-exonucleasePawan Kumar, Rohan Degaonkar, Dale C Guenther, et al.
Journal of the American Chemical Society|August 3, 2022
Role of a "Magic" Methyl: 2'-Deoxy-2'-α-F-2'-β-<i>C</i>-methyl Pyrimidine Nucleotides Modulate RNA Interference Activity through Synergy with 5'-Phosphate Mimics and Mitigation of Off-Target EffectsDale C Guenther, Shohei Mori, Shigeo Matsuda, et al.
Nature Communications|February 21, 2018
Selection of GalNAc-conjugated siRNAs with limited off-target-driven rat hepatotoxicityMaja M Janas, Mark K Schlegel, Carole E Harbison, et al.
Nucleic Acids Research|February 12, 2021
siRNAs containing 2'-fluorinated Northern-methanocarbacyclic (2'-F-NMC) nucleotides: in vitro and in vivo RNAi activity and inability of mitochondrial polymerases to incorporate 2'-F-NMC NTPsMasaaki Akabane-Nakata, Namrata D Erande, Pawan Kumar, et al.
Nucleic Acids Research|April 17, 2026
Acyclic serinol nucleic acid modification of siRNAs overcomes seed region mediated off-target effects while maintaining potencyTyler Chickering, Joel M Harp, Yongfeng Jiang, et al.
Journal of the American Chemical Society|August 28, 2023
Shorter Is Better: The α-(l)-Threofuranosyl Nucleic Acid Modification Improves Stability, Potency, Safety, and Ago2 Binding and Mitigates Off-Target Effects of Small Interfering RNAsShigeo Matsuda, Saikat Bala, Jen-Yu Liao, et al.
Nucleic Acids Research|June 23, 2022
From bench to bedside: Improving the clinical safety of GalNAc-siRNA conjugates using seed-pairing destabilizationMark K Schlegel, Maja M Janas, Yongfeng Jiang, et al.
Nature Medicine|April 8, 2015
An RNAi therapeutic targeting antithrombin to rebalance the coagulation system and promote hemostasis in hemophiliaAlfica Sehgal, Scott Barros, Lacramioara Ivanciu, et al.
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