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Bioorganic & Medicinal Chemistry Letters|June 7, 2015
Use of molecular modeling aided design to dial out hERG liability in adenosine A(2A) receptor antagonistsQiaolin Deng, Yeon-Hee Lim, Rajan Anand, et al.ACS Medicinal Chemistry Letters|December 18, 2020
Discovery of Highly Selective and Potent HDAC3 Inhibitors Based on a 2-Substituted Benzamide Zinc Binding GroupJian Liu, Younong Yu, Joseph Kelly, et al.Bioorganic & Medicinal Chemistry Letters|June 16, 2009
Diaminocyclobutenediones as potent and orally bioavailable CXCR2 receptor antagonists: SAR in the phenolic amide regionCynthia Aki, Jianping Chao, Johan A Ferreira, et al.Bioorganic & Medicinal Chemistry Letters|April 26, 2020
Discovery of ethyl ketone-based HDACs 1, 2, and 3 selective inhibitors for HIV latency reactivationWensheng Yu, Jian Liu, Younong Yu, et al.ACS Medicinal Chemistry Letters|July 18, 2020
Selective Class I HDAC Inhibitors Based on Aryl Ketone Zinc Binding Induce HIV-1 Protein for ClearanceJian Liu, Joseph Kelly, Wensheng Yu, et al.Journal of Medicinal Chemistry|April 2, 2021
Discovery of Ethyl Ketone-Based Highly Selective HDACs 1, 2, 3 Inhibitors for HIV Latency Reactivation with Minimum Cellular Potency Serum Shift and Reduced hERG ActivityWensheng Yu, Jian Liu, Dane Clausen, et al.Bioorganic & Medicinal Chemistry Letters|February 22, 2014
Quality by design (QbD) of amide isosteres: 5,5-Disubstituted isoxazolines as potent CRTh2 antagonists with favorable pharmacokinetic and drug-like propertiesDong Xiao, Xiaohong Zhu, Younong Yu, et al.Bioorganic & Medicinal Chemistry Letters|February 5, 2008
Synthesis and structure-activity relationships of heteroaryl substituted-3,4-diamino-3-cyclobut-3-ene-1,2-dione CXCR2/CXCR1 receptor antagonistsYounong Yu, Michael P Dwyer, Jianping Chao, et al.ACS Medicinal Chemistry Letters|October 16, 2024
Rapid Affinity and Microsomal Stability Ranking of Crude Mixture Libraries of Histone Deacetylase InhibitorsSriram Tyagarajan, Christine L Andrews, Douglas C Beshore, et al.Journal of Medicinal Chemistry|December 22, 2006
Discovery of 2-hydroxy-N,N-dimethyl-3-{2-[[(R)-1-(5- methylfuran-2-yl)propyl]amino]-3,4-dioxocyclobut-1-enylamino}benzamide (SCH 527123): a potent, orally bioavailable CXCR2/CXCR1 receptor antagonistMichael P Dwyer, Younong Yu, Jianping Chao, et al.Pageof 3