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The Journal of General Physiology|December 12, 2018
Extracellular protons accelerate hERG channel deactivation by destabilizing voltage sensor relaxationYu Patrick Shi, Samrat Thouta, Yen May Cheng, et al.
European Biophysics Journal : EBJ|December 24, 2013
External protons destabilize the activated voltage sensor in hERG channelsYu Patrick Shi, Yen May Cheng, Aaron C Van Slyke, et al.
Frontiers in Pharmacology|May 16, 2012
Voltage-dependent gating of HERG potassium channelsYen May Cheng, Tom W Claydon
Frontiers in Pharmacology|March 19, 2020
Modulation of hERG K+ Channel Deactivation by Voltage Sensor RelaxationYu Patrick Shi, Samrat Thouta, Thomas W Claydon
Biophysical Journal|March 11, 2014
Proline scan of the HERG channel S6 helix reveals the location of the intracellular pore gateSamrat Thouta, Stanislav Sokolov, Yuki Abe, et al.
American Journal of Physiology. Cell Physiology|April 21, 2012
Proton block of the pore underlies the inhibition of hERG cardiac K+ channels during acidosisAaron C Van Slyke, Yen May Cheng, Pouya Mafi, et al.
Biophysical Journal|March 27, 2015
NS1643 interacts around L529 of hERG to alter voltage sensor movement on the path to activationJiqing Guo, Yen May Cheng, James P Lees-Miller, et al.
The Journal of General Physiology|August 28, 2013
Functional interactions of voltage sensor charges with an S2 hydrophobic plug in hERG channelsYen May Cheng, Christina M Hull, Christine M Niven, et al.
Biophysical Journal|January 26, 2017
Stabilization of the Activated hERG Channel Voltage Sensor by Depolarization Involves the S4-S5 LinkerSamrat Thouta, Christina M Hull, Yu Patrick Shi, et al.
Scientific Reports|March 23, 2018
Investigating the state dependence of drug binding in hERG channels using a trapped-open channel phenotypeSamrat Thouta, Garman Lo, Lukas Grajauskas, et al.
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