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Clinical Pharmacokinetics|May 6, 2023
Estimation of FMO3 Ontogeny by Mechanistic Population Pharmacokinetic Modelling of Risdiplam and Its Impact on Drug-Drug Interactions in ChildrenYumi Cleary, Heidemarie Kletzl, Paul Grimsey, et al.
European Journal of Drug Metabolism and Pharmacokinetics|September 8, 2021
Physiologically-Based Pharmacokinetic Modelling of Entrectinib Parent and Active Metabolite to Support Regulatory Decision-MakingNassim Djebli, Vincent Buchheit, Neil Parrott, et al.
Clinical Pharmacology in Drug Development|August 23, 2016
Clinical Drug-Drug Interactions Through Cytochrome P450 3A (CYP3A) for the Selective ALK Inhibitor AlectinibPeter N Morcos, Yumi Cleary, Elena Guerini, et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals|October 8, 2021
Addressing Today's Absorption, Distribution, Metabolism, and Excretion (ADME) Challenges in the Translation of In Vitro ADME Characteristics to Humans: A Case Study of the SMN2 mRNA Splicing Modifier RisdiplamStephen Fowler, Andreas Brink, Yumi Cleary, et al.
British Journal of Clinical Pharmacology|October 11, 2018
A phase 1 healthy male volunteer single escalating dose study of the pharmacokinetics and pharmacodynamics of risdiplam (RG7916, RO7034067), a SMN2 splicing modifierStefan Sturm, Andreas Günther, Birgit Jaber, et al.
Clinical Pharmacology and Therapeutics|January 10, 2018
Physiologically Based Pharmacokinetic Model Qualification and Reporting Procedures for Regulatory Submissions: A Consortium PerspectiveMohamad Shebley, Punam Sandhu, Arian Emami Riedmaier, et al.
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