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Drug Metabolism and Pharmacokinetics|June 6, 2024
DMPK perspective on quantitative model analysis for chimeric antigen receptor cell therapy: Advances and challengesAkihiko Goto, Yuu Moriya, Miyu Nakayama, et al.
Biopharmaceutics & Drug Disposition|March 16, 2017
Influence of the pharmacokinetic profile on the plasma glucose lowering effect of the PPARγ agonist pioglitazone in Wistar fatty ratsAkihiko Goto, Yoshihiko Tagawa, Yoshiaki Kimura, et al.
Xenobiotica; the Fate of Foreign Compounds in Biological Systems|July 26, 2018
Investigation of disposition for TAK-448, a synthetic peptide of kisspeptin analog, in rats and dogs using the radiolabeled TAK-448 suitable for pharmacokinetic studyYuu Moriya, Akifumi Kogame, Yoshihiko Tagawa, et al.
Molecular Therapy. Methods & Clinical Development|August 8, 2025
Considerations in biodistribution evaluation of iPSC-derived cell therapy: A pancreatic islet cell case studyMiyu Nakayama, Yuu Moriya, Hikaru Ueno, et al.
Journal of Pharmaceutical and Biomedical Analysis|July 4, 2012
Development and validation of sensitive sandwich ELISAs for two investigational nonapeptide metastin receptor agonists, TAK-448 and TAK-683Nobuyo Yoshida, Naoki Nishizawa, Hisanori Matsui, et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals|June 16, 2019
The Enhancement of Subcutaneous First-Pass Metabolism Causes Nonlinear Pharmacokinetics of TAK-448 after a Single Subcutaneous Administration to RatsYuu Moriya, Akifumi Kogame, Yoshihiko Tagawa, et al.
Scientific Reports|October 22, 2020
Quantitative PCR methodology with a volume-based unit for the sophisticated cellular kinetic evaluation of chimeric antigen receptor T cellsSyunsuke Yamamoto, Shin-Ichi Matsumoto, Akihiko Goto, et al.
Xenobiotica; the Fate of Foreign Compounds in Biological Systems|March 21, 2018
Disposition and metabolism of the G protein-coupled receptor 40 agonist TAK-875 (fasiglifam) in rats, dogs, and humansAkifumi Kogame, Ronald Lee, Liping Pan, et al.
Biopharmaceutics & Drug Disposition|June 21, 2020
Pharmacokinetic and pharmacodynamic modeling of the metastin/kisspeptin analog, TAK-448, for its anti-tumor efficacy in a rat xenograft modelAkifumi Kogame, Kaori Ishikawa, Joost DeJongh, et al.
Regenerative Therapy|January 11, 2021
Development of a bioanalytical method for circulating human T cells in animals using Arthrobacter luteus-based quantitative polymerase chain reaction and its application in preclinical biodistribution studiesHisao Shimizu, Yoji Kuze, Tomoaki Higuchi, et al.
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