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Cold Spring Harbor Perspectives in Medicine|February 5, 2017
Therapeutic Strategies for Restoring Tau HomeostasisZapporah T Young, Sue Ann Mok, Jason E GestwickiACS Chemical Biology|October 30, 2018
A Local Allosteric Network in Heat Shock Protein 70 (Hsp70) Links Inhibitor Binding to Enzyme Activity and Distal Protein-Protein InteractionsSilvia Rinaldi, Victoria A Assimon, Zapporah T Young, et al.ACS Medicinal Chemistry Letters|December 7, 2013
Analogs of the Allosteric Heat Shock Protein 70 (Hsp70) Inhibitor, MKT-077, as Anti-Cancer AgentsXiaokai Li, Sharan R Srinivasan, Jamie Connarn, et al.Cell Chemical Biology|July 13, 2022
A campaign targeting a conserved Hsp70 binding site uncovers how subcellular localization is linked to distinct biological activitiesHao Shao, Shuhei Taguwa, Luke Gilbert, et al.ACS Chemical Neuroscience|March 12, 2013
Synthesis and initial evaluation of YM-08, a blood-brain barrier permeable derivative of the heat shock protein 70 (Hsp70) inhibitor MKT-077, which reduces tau levelsYoshinari Miyata, Xiaokai Li, Hsiu-Fang Lee, et al.Journal of Medicinal Chemistry|June 29, 2018
Exploration of Benzothiazole Rhodacyanines as Allosteric Inhibitors of Protein-Protein Interactions with Heat Shock Protein 70 (Hsp70)Hao Shao, Xiaokai Li, Michael A Moses, et al.Chemical Science|June 14, 2021
Tryptophan scanning mutagenesis as a way to mimic the compound-bound state and probe the selectivity of allosteric inhibitors in cellsIsabelle R Taylor, Victoria A Assimon, Szu Yu Kuo, et al.Cell Chemical Biology|August 9, 2016
Stabilizing the Hsp70-Tau Complex Promotes Turnover in Models of TauopathyZapporah T Young, Jennifer N Rauch, Victoria A Assimon, et al.Nature Communications|April 15, 2021
Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in miceBenjamin Caballero, Mathieu Bourdenx, Enrique Luengo, et al.Biological Psychiatry|April 24, 2013
Allosteric heat shock protein 70 inhibitors rapidly rescue synaptic plasticity deficits by reducing aberrant tauJose Abisambra, Umesh K Jinwal, Yoshinari Miyata, et al.Pageof 1