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Investigational New Drugs|March 12, 2021
Discovery of MTR-106 as a highly potent G-quadruplex stabilizer for treating BRCA-deficient cancersMeng-Zhu Li, Tao Meng, Shan-Shan Song, et al.
Molecular Cancer Therapeutics|February 20, 2007
R16, a novel amonafide analogue, induces apoptosis and G2-M arrest via poisoning topoisomerase IIHong Zhu, Min Huang, Fan Yang, et al.
Oncotarget|April 4, 2015
Dual targeting of microtubule and topoisomerase II by α-carboline derivative YCH337 for tumor proliferation and growth inhibitionJun-Mei Yi, Xiao-Fei Zhang, Xia-Juan Huan, et al.
Investigational New Drugs|July 4, 2019
A new BET inhibitor, 171, inhibits tumor growth through cell proliferation inhibition more than apoptosis inductionMohammadali Soleimani Damaneh, Jian-Ping Hu, Xia-Juan Huan, et al.
Molecular Cancer Therapeutics|November 21, 2007
MFTZ-1, an actinomycetes subspecies derived antitumor macrolide, functions as a novel topoisomerase II poisonCheng-Ying Xie, Hong Zhu, Li-Ping Lin, et al.
European Journal of Medicinal Chemistry|August 11, 2023
Identification of [1,2,4]Triazolo[4,3-a]pyrazine PARP1 inhibitors with overcome acquired resistance activitiesPingyuan Wang, Wen-Ting Zhu, Yajing Wang, et al.
Journal of Medicinal Chemistry|September 7, 2019
Structure-Based Discovery and Development of a Series of Potent and Selective Bromodomain and Extra-Terminal Protein InhibitorsJianping Hu, Chang-Qing Tian, Mohammadali Soleimani Damaneh, et al.
Cancer Research|September 19, 2007
Nonclassic functions of human topoisomerase I: genome-wide and pharmacologic analysesZe-Hong Miao, Audrey Player, Uma Shankavaram, et al.
EMBO Molecular Medicine|January 18, 2023
Thioparib inhibits homologous recombination repair, activates the type I IFN response, and overcomes olaparib resistanceLi-Min Wang, Pingyuan Wang, Xiao-Min Chen, et al.
Cancer Letters|November 17, 2016
Poly(ADP-ribose)polymerase (PARP) inhibition and anticancer activity of simmiparib, a new inhibitor undergoing clinical trialsBo Yuan, Na Ye, Shan-Shan Song, et al.
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