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Journal of Medicinal Chemistry|January 7, 2026
Discovery of 2,4-Disubstituted Pyrimidine Derivatives as Novel Kir4.1 Inhibitors with Rapid-Onset Antidepressant EffectSisi Wang, Mengdan Li, Chao Zhang, et al.Journal of Ethnopharmacology|September 10, 2013
Natural product vindoline stimulates insulin secretion and efficiently ameliorates glucose homeostasis in diabetic murine modelsXin-gang Yao, Fanglei Chen, Ping Li, et al.Nature Communications|June 5, 2026
Cryo-EM structures of heteromeric Kir4.1/5.1 channel suggest mechanisms of inward rectification and channel blockageYingjie Ning, Xiaoyu Zhou, Yimin Zhang, et al.Current Research in Microbial Sciences|June 16, 2025
Screening and discovery of an antiviral candidate inhibiting the SARS-CoV-2 envelope (2-E) channelHan Zhang, Shuxin Shi, Lujia Sun, et al.BMC Biology|February 5, 2024
An LQT2-related mutation in the voltage-sensing domain is involved in switching the gating polarity of hERGZhipei Liu, Feng Wang, Hui Yuan, et al.Nature Communications|October 19, 2023
Ligand activation mechanisms of human KCNQ2 channelDemin Ma, Yueming Zheng, Xiaoxiao Li, et al.Advanced Science (Weinheim, Baden-Wurttemberg, Germany)|December 3, 2025
Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid-Onset Antidepressant Agent in MiceSisi Wang, Xiaoyu Zhou, Mengdan Li, et al.Plos Pathogens|November 14, 2025
The B169L protein of African swine fever virus functions as a viroporin that activates the calcium-mediated inflammasomeJiaqi Li, Qiguang Li, Yanjin Wang, et al.Journal of Medicinal Chemistry|July 22, 2024
Discovery of Novel Pyrimidine-Based Derivatives as Nav1.2 Inhibitors with Efficacy in Mouse Models of EpilepsyGuoxue He, Yueming Zheng, Shunzhen Chang, et al.Nature Biomedical Engineering|September 29, 2020
An electric-field-responsive paramagnetic contrast agent enhances the visualization of epileptic foci in mouse models of drug-resistant epilepsyCong Wang, Wanbing Sun, Jun Zhang, et al.Pageof 9