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Journal of Medicinal Chemistry|June 3, 2017
Application of Structure-Based Design and Parallel Chemistry to Identify a Potent, Selective, and Brain Penetrant Phosphodiesterase 2A InhibitorChristopher J Helal, Eric P Arnold, Tracey L Boyden, et al.Nature Metabolism|November 24, 2020
An enolase inhibitor for the targeted treatment of ENO1-deleted cancersYu-Hsi Lin, Nikunj Satani, Naima Hammoudi, et al.Journal of Medicinal Chemistry|January 3, 2018
Identification of a Potent, Highly Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor Clinical CandidateChristopher J Helal, Eric Arnold, Tracey Boyden, et al.Nature Communications|September 11, 2021
Mammary-specific expression of Trim24 establishes a mouse model of human metaplastic breast cancerVrutant V Shah, Aundrietta D Duncan, Shiming Jiang, et al.Journal of Medicinal Chemistry|December 4, 2024
Discovery of ART0380, a Potent and Selective ATR Kinase Inhibitor Undergoing Phase 2 Clinical Studies for the Treatment of Advanced or Metastatic Solid CancersChristopher L Carroll, Michael G Johnson, Yanbing Ding, et al.Journal of Medicinal Chemistry|October 29, 2020
Discovery of IPN60090, a Clinical Stage Selective Glutaminase-1 (GLS-1) Inhibitor with Excellent Pharmacokinetic and Physicochemical PropertiesMichael J Soth, Kang Le, Maria Emilia Di Francesco, et al.Cancer Research|September 15, 2020
Allosteric SHP2 Inhibitor, IACS-13909, Overcomes EGFR-Dependent and EGFR-Independent Resistance Mechanisms toward OsimertinibYuting Sun, Brooke A Meyers, Barbara Czako, et al.Nature Medicine|June 13, 2018
An inhibitor of oxidative phosphorylation exploits cancer vulnerabilityJennifer R Molina, Yuting Sun, Marina Protopopova, et al.Pageof 2