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Journal of Medicinal Chemistry|May 20, 2024
Development of Novel Phosphonodifluoromethyl-Containing Phosphotyrosine Mimetics and a First-In-Class, Potent, Selective, and Bioavailable Inhibitor of Human CDC14 PhosphatasesJiajun Dong, Brenson A Jassim, Kedric L Milholland, et al.
Chemical Science|January 21, 2026
Protein tyrosine phosphatase inactivation by electrophilic tyrosine modificationMadeleine L Ware, David M Leace, Zihan Qu, et al.
Biorxiv : the Preprint Server for Biology|February 20, 2025
Discovery of Chirally-dependent Protein <i>O</i>-2-Hydroxyglutarylation by D2HG and L2HGZheng Zhang, Yi-Kai Liu, Zhuojun Luo, et al.
Biorxiv : the Preprint Server for Biology|July 3, 2023
A small molecule inhibitor of PTP1B and PTPN2 enhances T cell anti-tumor immunityShuwei Liang, Eric Tran, Xin Du, et al.
Chemical Science|November 29, 2023
Discovery of a selective TC-PTP degrader for cancer immunotherapyJinmin Miao, Jiajun Dong, Yiming Miao, et al.
The Journal of Clinical Investigation|June 6, 2024
Off-target autophagy inhibition by SHP2 allosteric inhibitors contributes to their antitumor activity in RAS-driven cancersYiming Miao, Yunpeng Bai, Jinmin Miao, et al.
Biorxiv : the Preprint Server for Biology|November 24, 2025
Synergistic effects of deleting the tyrosine phosphatases Shp1 and Shp2 on megakaryopoiesis and thrombopoiesis in miceElsa Barré, Marc-Damien Lourenco-Rodrigues, Lucie Zimmermann, et al.
Nature Chemistry|March 18, 2026
Discovery of chirally dependent protein modifications by D- and L-2-hydroxyglutaratesZheng Zhang, Yi-Kai Liu, Zhuojun Luo, et al.
3 Biotech|May 25, 2026
Design, synthesis, and in-vitro evaluation of 2-(heteroarylthio)acetamido-1<i>H</i>-benzo[<i>d</i>]imidazole derivatives as PTP1B inhibitors for the treatment of type 2 diabetesPraveen Kumar, Benjamin Ayodipupo Babalola, Zihan Qu, et al.
Angewandte Chemie (International Ed. in English)|March 27, 2023
Small Molecule Degraders of Protein Tyrosine Phosphatase 1B and T-Cell Protein Tyrosine Phosphatase for Cancer ImmunotherapyJiajun Dong, Jinmin Miao, Yiming Miao, et al.
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