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Protein Science : a Publication of the Protein Society|November 13, 2025
The pathogenic E139D mutation stabilizes a non-canonical active state of the multi-domain phosphatase SHP2Anne E van Vlimmeren, Ziyuan Jiang, Deepti Karandur, et al.
Biorxiv : the Preprint Server for Biology|July 9, 2025
Multiplexed single-cell transcriptomics reveals diverse phenotypic outcomes for pathogenic SHP2 variantsAnne E van Vlimmeren, Ross M Giglio, Ziyuan Jiang, et al.
Science Advances|May 22, 2026
Multiplexed single-cell transcriptomics reveals diverse phenotypic outcomes for pathogenic SHP2 variantsAnne E van Vlimmeren, Ross M Giglio, Ziyuan Jiang, et al.
Scientific Reports|December 8, 2025
Transcriptome analysis of orbital tissue in thyroid eye disease uncovers key pathogenic mediatorsWumei Hua, Xiaolan Ji, Jingqiao Chen, et al.
Biorxiv : the Preprint Server for Biology|February 20, 2025
Allosteric inhibition rescues hydrocephalus caused by catalytically inactive Shp2Neoklis Makrides, Emily Sun, Hilal Mir, et al.
Biorxiv : the Preprint Server for Biology|July 28, 2023
The pathogenic T42A mutation in SHP2 rewires the interaction specificity of its N-terminal regulatory domainAnne E van Vlimmeren, Rashmi Voleti, Cassandra A Chartier, et al.
Proceedings of the National Academy of Sciences of the United States of America|July 16, 2024
The pathogenic T42A mutation in SHP2 rewires the interaction specificity of its N-terminal regulatory domainAnne E van Vlimmeren, Rashmi Voleti, Cassandra A Chartier, et al.
EMBO Reports|December 22, 2025
Proximity-labeling proteomics reveals remodeled interactomes and altered localization of pathogenic SHP2 variantsAnne E van Vlimmeren, Lauren C Tang, Ziyuan Jiang, et al.
Biorxiv : the Preprint Server for Biology|July 15, 2025
Proximity-labeling proteomics reveals remodeled interactomes and altered localization of pathogenic SHP2 variantsAnne E van Vlimmeren, Lauren C Tang, Ziyuan Jiang, et al.
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