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ACS Medicinal Chemistry Letters|August 20, 2026
Novel Compounds as Orexin 2 Receptor Agonists for Treating NarcolepsyRam W Sabnis, Anika R Sabnis
ACS Medicinal Chemistry Letters|September 15, 2026
Discovery of High-Affinity Peptide Ligands Targeting the SPIN1 Tudor 3 Domain Via a Minimalist Pruning StrategyAlessandra Feoli, Giulio Esposito, Manuela Grimaldi, et al.
ACS Medicinal Chemistry Letters|September 15, 2026
Multiscale Explainable Machine Learning Reveals Descriptor-Invariant Molecular Determinants of Small-Molecule PD-1/PD-L1 InhibitionAbdul Manan, Sidra Ilyas
ACS Medicinal Chemistry Letters|September 15, 2026
Molecular Striptease of a Thiadiazolopyrimidine Hit Yields a Streamlined, Artifact-Free NADPH Mimic for NOX InhibitionEmanuele Fabbrizi, Andrea Mancini, Chiara Lambona, et al.
ACS Medicinal Chemistry Letters|September 15, 2026
Improved Library of Pyrrolidine-2,3-dione Monomers as Antimicrobial and Antibiofilm Agents against Staphylococcus aureusSanjay R Kalliat, M Alejandro Valdes-Pena, Joshua G Pierce
ACS Medicinal Chemistry Letters|September 15, 2026
Discovery of Novel Small-Molecule Toll-like Receptor 2 Agonists via a Scaffold Hopping StrategyYueyue Zhu, Longhai Wang, Yuqi Chen, et al.
ACS Medicinal Chemistry Letters|September 15, 2026
De Novo Design in an M1 Positive Allosteric Modulator Backup Program: The Discovery of VU6069863Changho Han, Upendra Rathnayake, Alison R Gregro, et al.
ACS Medicinal Chemistry Letters|September 15, 2026
Novel Phosphodiesterase‑2 Inhibitors Discovered via Structure-Based Virtual Screening Targeting the Allosteric GAF‑B DomainCharles Adeniran, Gadam Myratgeldiyev, Fang Zheng, et al.
ACS Medicinal Chemistry Letters|September 15, 2026
Crystal Structure of the Sigma‑2 Receptor Complexed with Investigational Drug Zervimesine (CT1812)Gary C Look, Dominic Gilzer, Franziska Preuss, et al.
ACS Medicinal Chemistry Letters|October 16, 2020
Development of a Potent Brain-Penetrant EGFR Tyrosine Kinase Inhibitor against Malignant Brain TumorsJonathan E Tsang, Lorenz M Urner, Gyudong Kim, et al.
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