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ACS Medicinal Chemistry Letters|January 25, 2021
Multiresidue Tetrapeptide Substitutions Yield a 140-fold Selective Melanocortin-3 over Melanocortin-4 Receptor AgonistMark D Ericson, Romessa Shaikh, Courtney M Larson, et al.
ACS Medicinal Chemistry Letters|January 25, 2021
Discovery of DS79932728: A Potent, Orally Available G9a/GLP Inhibitor for Treating β-Thalassemia and Sickle Cell DiseaseKatsushi Katayama, Ken Ishii, Hideki Terashima, et al.
ACS Medicinal Chemistry Letters|January 25, 2021
Discovery of PIPE-359, a Brain-Penetrant, Selective M1 Receptor Antagonist with Robust Efficacy in Murine MOG-EAEThomas O Schrader, Yifeng Xiong, Ariana O Lorenzana, et al.
ACS Medicinal Chemistry Letters|February 19, 2021
Development of a Hematopoietic Prostaglandin D Synthase-Degradation InducerHidetomo Yokoo, Norihito Shibata, Miyako Naganuma, et al.
ACS Medicinal Chemistry Letters|February 16, 2017
Optimization of 3-Pyrimidin-4-yl-oxazolidin-2-ones as Allosteric and Mutant Specific Inhibitors of IDH1Julian R Levell, Thomas Caferro, Gregg Chenail, et al.
ACS Medicinal Chemistry Letters|February 16, 2017
Ca2+ Selective Host Rotaxane Is Highly Toxic Against Prostate Cancer CellsDavid B Smithrud, Lucas Powers, Jennifer Lunn, et al.
ACS Medicinal Chemistry Letters|August 16, 2019
Successful Strategies for Mitigation of a Preclinical Signal for Phototoxicity in a DGAT1 InhibitorTyler J Harrison, Daniel Bauer, Alina Berdichevsky, et al.
ACS Medicinal Chemistry Letters|August 16, 2019
Rotational Freedom, Steric Hindrance, and Protein Dynamics Explain BLU554 Selectivity for the Hinge Cysteine of FGFR4Xiaojing Lin, Yuliana Yosaatmadja, Maria Kalyukina, et al.
ACS Medicinal Chemistry Letters|August 16, 2019
Identification of CB1 Receptor Allosteric Sites Using Force-Biased MMC Simulated Annealing and Validation by Structure-Activity Relationship StudiesDow P Hurst, Sumanta Garai, Pushkar M Kulkarni, et al.
ACS Medicinal Chemistry Letters|August 16, 2019
Discovery of GSK2798745: A Clinical Candidate for Inhibition of Transient Receptor Potential Vanilloid 4 (TRPV4)Carl A Brooks, Linda S Barton, David J Behm, et al.
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