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ACS Pharmacology & Translational Science|December 19, 2024
Aptamer Proteolysis-Targeting Chimeras (PROTACs): A Novel Strategy to Combat Drug Resistance in Estrogen Receptor α-Positive Breast CancerYing Feng, Zhilin Zhang, Haowei Zhang, et al.
ACS Pharmacology & Translational Science|December 19, 2024
Repurposing Drugs and Synergistic Combinations as Potential Therapies for Inhibiting SARS-CoV-2 and Coronavirus ReplicationRichard Boulon, Clément Mazeaud, Majid D Farahani, et al.
ACS Pharmacology & Translational Science|December 19, 2024
Discovery of 7,9-Dibromo-dihydrodibenzofuran as a Potent Casein Kinase 2 (CK2) Inhibitor: Synthesis, Biological Evaluation, and Structural Studies on E-/Z-IsomersHendrik Rumler, Claudia Schmithals, Christian Werner, et al.
ACS Pharmacology & Translational Science|December 19, 2024
A Comparative Pharmacokinetics Study of Orally and Intranasally Administered 8-Nitro-1,3-benzothiazin-4-one (BTZ043) Amorphous Drug NanoparticlesFeng Li, Franziska Marwitz, David Rudolph, et al.
ACS Pharmacology & Translational Science|December 19, 2024
Hyperglycemia-Driven Insulin Signaling Defects Promote Parkinson's Disease-like Pathology in MiceRitu Soni, Kirti Mathur, Hritik Rathod, et al.
ACS Pharmacology & Translational Science|December 19, 2024
Cell Membrane Hybrid Liposome-Targeted Delivery of the Heat Shock Protein 90 C-Terminal Inhibitor for the Treatment of Idiopathic Pulmonary FibrosisJingwen Yang, Danya Lu, Yuping Sun, et al.
ACS Pharmacology & Translational Science|December 19, 2024
Off-Target Inhibition of Human Dihydroorotate Dehydrogenase (hDHODH) Highlights Challenges in the Development of Fat Mass and Obesity-Associated Protein (FTO) InhibitorsMarco Tarullo, Guillermo Fernandez Rodriguez, Alessia Iaiza, et al.
ACS Pharmacology & Translational Science|December 19, 2024
Effective, but Safe? Physiologically Based Pharmacokinetic (PBPK)-Modeling-Based Dosing Study of Molnupiravir for Risk Assessment in Pediatric SubpopulationsSarang Mishra, Katharina Rox
ACS Pharmacology & Translational Science|December 19, 2024
Mechanisms and Therapeutic Strategies for Myocardial Ischemia-Reperfusion Injury in Diabetic StatesJing Xue, Jialu Zhuang, Xinyue Wang, et al.
ACS Pharmacology & Translational Science|December 19, 2024
Challenging Reported Frizzled-Targeting Compounds in Selective Assays Reveals Lack of Functional Inhibition and Claimed ProfilesAlexey Koval, Cédric Boudou, Vladimir L Katanaev
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