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Bioorganic Chemistry|October 23, 2025
Novel cyclometalated iridium(III) complexes with a π-expansive benzothiophene ligand for enhanced photodynamic therapy against human osteosarcoma by disrupting Iron homeostasisZhewen Deng, Qing Zhang, Jie Zhu, et al.
Bioorganic Chemistry|October 31, 2025
Discovery of a spirocyclic influenza RNA-dependent RNA polymerase inhibitorJianxun He, Zhaoxing Chu, Qinlong Xu, et al.
Bioorganic Chemistry|October 30, 2025
Chitosan/polyacrylic acid nanogel-mediated delivery system for cancer treatment: Design, synthesis, ADMET, docking of thiazole derivatives as dual inhibitors of VEGFR-2 and EGFRT790MMohamed A Abdelgawad, Nashwa M Saleh, Felemban Athary Abdulhaleem M, et al.
Bioorganic Chemistry|October 30, 2025
Titanocene-derivative complex modified with a myristic-like aliphatic chain exhibits anticancer activity in vitro and in vivo by cisplatin-alternative mechanismsLaura Lopez-Sanz, Marta Carmen Guadamillas, Virginia Perez Garrido, et al.
Bioorganic Chemistry|November 2, 2025
Squaric-acid-engineered FAP2286: A next-generation 68Ga/177Lu theranostic ligand with synergistically enhanced affinity, hydrophilicity, and tumor retentionYuxiao Xia, Jianpeng Cao, Xue Jiang, et al.
Bioorganic Chemistry|November 1, 2025
Asperaucystins A - L: Austocystins with immunosuppressive and cytotoxic activities from Aspergillus ustus NRRL 5856Chunlun Qin, Yinhui Zhou, Xiaokun Yu, et al.
Bioorganic Chemistry|October 19, 2025
A novel piperazine-linked BODIPY-pyrimidine anti-tumor fluorescent active drug: targeting mechanism, real-time dynamic imaging and delivery effect of DSPC/DPIC nanoparticlesPei Su, Zhenning Wang, Tiantian Chai, et al.
Bioorganic Chemistry|October 14, 2025
Construction of an AND logic gate fluorescent probe for highly efficient detection of formaldehyde and Pim-1 kinaseBingxin Zhu, Shihua Yu, Shanshan Wang, et al.
Bioorganic Chemistry|October 14, 2025
Hit-to‑lead optimization of new carbazoles as potential anticancer agents via targeting human topoisomerase IIPritam Maity, Farman Ahmad, Poonam Yadav, et al.
Bioorganic Chemistry|October 9, 2025
Small-molecule inhibitors of GSK3β: Therapeutic potential and structure-activity relationship in multiple systemsJiale Wang, Dan Wang, Fanfei Liu, et al.
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