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Bioorganic Chemistry|March 29, 2026
A novel β-glucosidase from Lacticaseibacillus rhamnosus: Catalytic specificity and efficient production of high-value rare ginsenosidesXiaoxue Zhou, Zhezhe Li, Lei Xiong, et al.
Bioorganic Chemistry|March 29, 2026
Structure-guided design of icaritin-based scaffold modifications for enhanced osteoporotic therapyRui-Yue Liu, Ze-Kun Chen, Hui-Ru Liu, et al.
Bioorganic Chemistry|April 24, 2026
Discovery and development of the preclinical candidate (SH-1092), a potent third generation EGFR inhibitor for the treatment of NSCLCKejun Liu, Feiwan Zou, He Zhang, et al.
Bioorganic Chemistry|April 7, 2026
PEGylated organophosphorus hydrolase combined with butyrylcholinesterase: dual-enzyme synergistic biocatalysis for acute organophosphate poisoningChengcai Wang, Dan Wang, Ming Ma, et al.
Bioorganic Chemistry|April 16, 2026
Network pharmacology study and preclinical validation highlight the anti-diabetic potential of Persicaria lapathifolia (L.) Delarbre leaf extract via AMPK/Akt pathwaysPrachi Mehta, Dipankar Saha, Bhrigu Kumar Das
Bioorganic Chemistry|March 19, 2026
Gossypol suppresses tumorigenesis through inhibition of multiple deubiquitinating enzymesLin Gui, Chunying Chen, Jing Gao, et al.
Bioorganic Chemistry|March 19, 2026
A unique compound 3c targets GSK-3β and metal ion, interferes with tau and metal dyshomeostasis, promotes neurite outgrowth, decreases Aβ accumulation and ABTS•+, and enhances zebrafish motilityJing Zhang, Ying Li, Yan-Peng Li, et al.
Bioorganic Chemistry|March 23, 2026
Targeting cholinergic dysfunction and neuroinflammation through rationally designed Thieno[3,2-d]pyrimidine hybridsFeyzi Sinan Tokalı, Ozden Ozgun Acar, Yeliz Demir, et al.
Bioorganic Chemistry|March 24, 2026
Pyrvinium pamoate inhibits the survival of intracellular Mycobacterium tuberculosis through suppression of macrophage ferroptosisQing Guan, Yuanyuan Zhou, Jian-Li Han, et al.
Bioorganic Chemistry|April 10, 2026
Insights into a new class of antileishmanial compounds: an in vitro and in silico study of 1,2,4-oxadiazol-5(4H)-one derivativesLarissa G Maciel, Janaína V Dos Anjos, Julyanne M S de Sousa, et al.
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