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Bioorganic Chemistry|August 8, 2026
Ruthenium(II) complex enhances anti-breast cancer immune responses by inducing pyroptosis and immunogenic cell death while activating the cGAS-STING pathwayYuqing Zhang, Yuling Li, Jiaen Huang, et al.
Bioorganic Chemistry|July 27, 2026
Why JAK3 selectivity matters: biology, approved JAK inhibitors, and medicinal chemistry perspectivesSara Dias, Roberto Parise-Filho
Bioorganic Chemistry|August 7, 2026
Design of fluorinated triazinoindoles as highly potent and markedly selective ALR2 inhibitors: synthesis, in silico and in vitro evaluation of promising lead compoundsLucia Kovacikova, Terezia Teplanova, Magdalena Majekova, et al.
Bioorganic Chemistry|August 1, 2026
A facile synthesis, biological evaluation, ADMET profiling and computational insights of novel triazole-linked tetrahydrobenzo[b]thiophenes: A sonochemical click synthetic strategy in recyclable ionic liquid mediumSunita Kurahatti, Rajesh G Kalkhambkar, Nagarjuna Prakash Dalbanjan
Bioorganic Chemistry|July 29, 2026
Expansion of pyrrole-2-carboxylic acid-based metallo-β-lactamase inhibitors: C4 functionalization drives dual NDM/VIM inhibitionTatiana S Shkuratova, Kirill V Rychev, Vitaly G Grigorenko, et al.
Bioorganic Chemistry|August 5, 2026
Undescribed cucurbitacin-type triterpenoids from the roots of Trichosanthes cucumeroides with antitumor effects, and their molecular docking studiesMuhammad Aamer, Feibing Huang, Di Xiao, et al.
Bioorganic Chemistry|August 30, 2026
Repurposing butoconazole as a GRP78 substrate-binding domain (SBD) inhibitor to induce endoplasmic reticulum stress-mediated apoptosis in triple-negative breast cancerYaowen Song, Ziyue Yuan, Zhijia Li, et al.
Bioorganic Chemistry|August 29, 2026
Discovery and mechanistic benchmarking of ACE inhibitory Di- and tripeptidesYi Li, Yongqiang Cheng, Ning Tang
Bioorganic Chemistry|August 29, 2026
A Pyrazole-Amide-Azobenzene scaffold for the photocontrollable modulation of succinate dehydrogenase: synthesis, photophysical and biological propertiesHaoran Hu, Wenbin Tang, Jiayu Li, et al.
Bioorganic Chemistry|August 29, 2026
Discovery of anti-inflammatory β-acids featuring an unusual 5/7/5 tricyclic skeleton via targeting the TLR4/MyD88 signaling pathwayKang Ding, Fu-Lin Zhou, Yan-Jing Shi, et al.
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