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Bioorganic Chemistry|November 13, 2025
1,2,3-Triazole-modified sorafenib derivatives induce DNA damage, apoptosis, and PI3K/AKT pathway suppression in hepatocellular carcinoma: Design, synthesis, and evaluationLongfei Mao, Junfei Wu, Yimian Wang, et al.
Bioorganic Chemistry|November 4, 2025
Novel deep eutectic solvents promote enzyme-substrate molecular dynamic adaptation to enhance sucrose ester synthesis efficiencyZhiheng Chen, Binbin Nian, Yuan Qi, et al.
Bioorganic Chemistry|November 4, 2025
Design, synthesis, bioactivity evaluation, and molecular modeling of pyridin-2-yl-pyrimidine: Potential Antimicrobial and anti-tuberculosis agentsXue Xia, Jian Shen, Jindong Dai, et al.
Bioorganic Chemistry|November 2, 2025
Cafeic acid benzylidene hydrazides as novel procaspase-3 activators: Rational design, synthesis, and mechanistic evaluation of antitumor efficacyZhongyuan Guo, Run Wang, Qingsi Zhao, et al.
Bioorganic Chemistry|November 5, 2025
A comprehensive description of VEGF-R1/2 small molecule inhibitors as anticancer agentsYufei Zhao, Hongyuan Lu
Bioorganic Chemistry|October 28, 2025
Lipidization of gelsemine facilitates its cellular uptake and anti-tumor activityZhiwei Wang, Xingjun Xu, Hui Wen, et al.
Bioorganic Chemistry|October 22, 2025
Enantiomeric neolignans from Ficus erecta and their neuroprotective activities against 6-OHDA-induced oxidative stress via Nrf2/HO-1 pathway activation in PC12 cellsWenming Wu, Lifang Luo, Xiangping Jia, et al.
Bioorganic Chemistry|October 4, 2025
Structure-activity optimization of Deferasirox-derived aroyl hydrazones: Synthesis, DFT characterization, and mechanistic insights into selective anticancer activity against colon and breast cancerÖmer Dilek, Muzaffer Dükel, Fatema Zarzour, et al.
Bioorganic Chemistry|October 4, 2025
Lujiao Formula attenuates cardiac hypertrophy by modulating AMPK-SIRT1 and PI3K-Akt signaling pathwaysJianwei Zhang, Jie Shen, Wei Liu, et al.
Bioorganic Chemistry|October 3, 2025
Supramolecular engineering of J-aggregated BODIPY derivatives with assembly-enhanced ROS generation for mitochondrial Cancer therapyChun-Lin Yu, Xue-Liang Liu, Guo-Jiang Mao, et al.
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