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Bioorganic Chemistry|November 1, 2025
Disruption of cellular redox homeostasis by bigelovin triggers oxidative stress-mediated apoptosis in FibrosarcomaJunmin Xi, Qingfeng Wu, Yuwei Wang, et al.
Bioorganic Chemistry|September 25, 2025
An easily accessible fluorometric probe for selective cyanide detection via nucleophilic addition: Applications to environmental water samples, smartphone, and bio-imaging of fungi and plantsBoeun Choi, Sooseong Lee, Hyejin Nam, et al.
Bioorganic Chemistry|September 26, 2025
Synthesis and biological evaluation of novel naproxen-phenacetin triazole hybrids as promising anti-inflammatory agents with enhanced gastrointestinal tolerabilityAhmet Avci, Hayrünnisa Taşci, Begüm Nurpelin Sağlık Özkan, et al.
Bioorganic Chemistry|September 20, 2025
Usenamine A, an RGS2 inhibitor, exerts anti-NSCLC activity and enhances cytotoxicity of gemcitabine by inducing ER stress and Notch1-mediated autophagyLiyuan Cheng, Hailong Li, Chenjun Xie, et al.
Bioorganic Chemistry|September 19, 2025
Synthesis and biological evaluations of 1,3,4-thiadiazole derivatives as dual acting enzyme inhibitors to target inflammation and diabetesWaqas Ahmad, Basharat Ali, Bibi Hadiqa, et al.
Bioorganic Chemistry|September 19, 2025
Design and synthesis of new Thieno[2,3-d]pyrimidine-based derivatives as anti-breast cancer: Biological evaluation, PIM-1 kinase inhibition, and in silico studiesMenna Tallah M Sayed, Zeinab Mahmoud, Makarem M Said, et al.
Bioorganic Chemistry|September 16, 2025
Discovery of adamantane-containing small-molecule peptidomimetics with membrane-disrupting activity for combating drug-resistant BacteriaJie Su, Yuhang He, Min Li, et al.
Bioorganic Chemistry|August 14, 2025
Rational discovery of novel tetrahydroisoquinoline-indole derivatives as potent P-glycoprotein inhibitor against multidrug resistance in MCF-7/ADR cellZhikun Yang, Leyi Ying, Ning Yang, et al.
Bioorganic Chemistry|August 15, 2025
A pomalidomide-based gefitinib PROTAC degrader effectively inhibits lung cancer progression in EGFR-TKIs-acquired resistant models by targeting EGFR degradation and ETFA-mediated ATP generationLiangping Li, Yongkun Li, Xuesong Ma, et al.
Bioorganic Chemistry|August 14, 2025
Roridin E and satratoxin H, macrocyclic trichothecene mycotoxins, induce endoplasmic reticulum stress-dependent apoptosis through ribosome interaction in B16 mouse melanoma cellsJunghyun Lee, Kyung Ah Kim, Eunbi Yu, et al.
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