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Bioorganic Chemistry|January 24, 2026
2-Aminothiophene and 2-aminothiazole scaffolds as potent antimicrobial agents: Design, synthesis, biological evaluation, and computational insightsMunugala Chandrakanth, Jyothi Kumari, Paramita Pakhira, et al.Bioorganic Chemistry|January 25, 2026
Pharmacological inhibition of histone Lactylation enhances immunotherapy efficacy in gastrointestinal cancersBoao Li, Liang Jiao, Yueyan ZhangBioorganic Chemistry|January 23, 2026
Antifungal activity of AR-12 and its derivatives against clinically relevant fusarium solani isolates in keratitisYihui Ma, Lei Han, Yujuan Wang, et al.Bioorganic Chemistry|January 20, 2026
Reconnecting new tetrahydrobenzothieno-4-pyrimidine amides as potent PIM-1 kinase inhibitors via an integrated ligand, machine learning model and structure based scaffold hopping: In vitro anti-tumor investigationsVinayak Walhekar, Amol Muthal, Mahesh Ghaisas, et al.Bioorganic Chemistry|January 22, 2026
4-[(Aryloylhydrazineylidene)methyl]-N-phenylbenzamides as a new class of antimycobacterial agents: design, synthesis and biological evaluationVáclav Pflégr, Apolena Koklarová, Jiřina Stolaříková, et al.Bioorganic Chemistry|January 11, 2026
Discovery of novel pyridazinone derivatives as EGFRWT/ EGFRT790M kinase inhibitors; design, synthesis, antitumor evaluation, and molecular dynamic simulationsSara Y Ewieda, Eman M Ahmed, Peter A Halim, et al.Bioorganic Chemistry|February 4, 2026
Novel thiadiazole derivatives: synthesis, in silico, in vitro and in vivo evaluation of analgesic and anti-inflammatory activitiesHazal Eken, Derya Osmaniye, Berkant Kurban, et al.Bioorganic Chemistry|January 24, 2026
Multifunctional hydroquinone-1,2,3-triazole hybrids: Synthesis, biological evaluation, molecular docking, ADMET profiling, and in silico mechanistic insights as potential therapeutic agentsSultan Onur, Mustafa Çeşme, Ferhan TümerBioorganic Chemistry|January 22, 2026
Discovery and mechanistic insights of novel Piperlongumine analogs as potent Bcr-Abl kinase inhibitorsGuanglong Zhang, Xuesha Long, Xue Yang, et al.Bioorganic Chemistry|January 23, 2026
Novel Hsp90 inhibitors as leads for the development of radiotheragnostics for Meitner-Auger electron therapyAlexandra K Kennedy, Miguel Angel Herrera-Rueda, Reese Wilby, et al.Pageof 868