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Bioorganic Chemistry|January 28, 2026
Design, synthesis and biological evaluation of sulfur-containing epicaryolane derivatives as FXR agonistsJi-Long Zou, Da-Yu Shi, Yi-Zhou Xiang, et al.
Bioorganic Chemistry|December 11, 2025
Discovery of potent indole-2-one-based BRD4 PROTACs for the treatment of acute myeloid leukemiaZhao-Yang Wang, Yi-Ru Wang, Fengya Ge, et al.
Bioorganic Chemistry|December 7, 2025
Quinolinyl-appended chalcones as promising antiproliferative and trypanocidal agents: Synthesis, biological profiling, and further transformation into novel benzo[f]pyrazolo[5,1-a][2,7]naphthyridine and quinoline-pyrido[2,3-d]pyrimidin-2,4-dione hybridsDiego Rodríguez, Elizabeth Gómez, Mauricio Moncada-Basualto, et al.
Bioorganic Chemistry|December 4, 2025
Gypenoside L inhibits oral squamous cell carcinoma progression by targeting the AKT signaling pathwayDan-Ye Lai, Yu Chen, Ting Lan, et al.
Bioorganic Chemistry|December 4, 2025
Ellagic acid derivatives as potential inhibitors of melanoma cell metastasis: Insights into MMP-related mechanismsShervin Qatran, Fatemehsadat Hosseini, Milad Iranshahy, et al.
Bioorganic Chemistry|December 13, 2025
Design, synthesis, and multi-target evaluation of Chromone-based derivatives as promising anti-Alzheimer's disease agentsJia Hao Lu, Chen Hao Zhao, Ying Qi Qiu, et al.
Bioorganic Chemistry|December 5, 2025
Discovery of novel quinazoline analogs as tubulin inhibitors targeting the colchicine binding site for potent antitumor therapy in combination with PD-L1 inhibitorsYichang Ren, Songwen Zhou, Chenglong Xu, et al.
Bioorganic Chemistry|December 11, 2025
Casbane diterpenoids from Euphorbiaceae suppresse neuroinflammation by regulating microglia polarization via inhibiting NF-κB signalingBaojun Su, Yaqi Wang, Haiyan Zhao, et al.
Bioorganic Chemistry|December 4, 2025
A Golgi-targeted regenerated fluorescence probe for the detection of formaldehyde and its imaging applications in living cells and zebrafishBingxin Zhu, Yao Wang, Binhan Lv, et al.
Bioorganic Chemistry|November 25, 2025
Antioxidant mechanism of Edaravone and its amine analogs: Combined kinetic and DFT studyStanislav A Grabovskii, Almaz R Migranov, Lucija R Yakupova, et al.
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