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Bioorganic Chemistry|February 21, 2026
Electrophilic warhead engagement and structure-activity relationship of Benzothiazole-based putative covalent inhibitors targeting SARS-CoV-2 Main proteaseSofia Kanwal, Anees Saeed, Ayesha Tahir, et al.
Bioorganic Chemistry|March 24, 2026
Unveiling antibacterial and α-amylase inhibitory potentials of Opuntia ficus-indica aqueous extract through LC-ESI-MS/MS-guided in vitro and in silico investigationAbdelmalek Zaater, Sara Touati, Mohammed Messaoudi, et al.
Bioorganic Chemistry|March 31, 2026
UM-6 remodels the tumor immune microenvironment by blocking PD-L1 N-glycosylation and promoting ERAD-mediated degradation in cervical cancerDongying Wang, Jiaxing He, Shuying Wu, et al.
Bioorganic Chemistry|March 19, 2026
A potent icaritin derivative ameliorates Parkinson's disease via GPER-mediated mitophagy restoration and dopaminergic neuroprotectionXiaowen Wang, Xizhen Cao, Meiyun Cai, et al.
Bioorganic Chemistry|March 27, 2026
Discovery of novel HDAC6 inhibitors based on the diphenyl-1,2,4-oxadiazole scaffold with potential efficacy in alleviating inflammation- and chemotherapy- associated mechanical hypersensitivityLong Yin, Mingyue Yin, Zhiyuan Fan, et al.
Bioorganic Chemistry|February 28, 2026
Dual-functional near-infrared fluorescent probe for H2S detection and precise COX-2-positive cancer imagingFei Zheng, Yanyan Zeng, Ye-Xin Liao, et al.
Bioorganic Chemistry|March 19, 2026
(1E,4E)-1,5-bis(2-bromo-4,5-dihydroxyphenyl)penta-1,4-dien-3-one alleviates hyperuricemia by inhibiting xanthine oxidaseQian Wang, Li Wang, Yaxin Guo, et al.
Bioorganic Chemistry|April 12, 2026
Design, synthesis and biological evaluation of peptidyl keto vinyl sulfones as cysteine proteases inhibitors. Effect of the peptide structure on the activitySergio de la Hoz-Rodríguez, Santiago Royo, Christian Kersten, et al.
Bioorganic Chemistry|May 3, 2026
Harnessing mitohormesis: A thiazole-based mitochondrial respiration inhibitor restores metabolic homeostasis in type 2 diabetesYang Zhang, Jie Guo, Jie Jin, et al.
Bioorganic Chemistry|April 9, 2026
Meloaxilines A-E, five unprecedented monoterpenoid indole alkaloids from Melodinus axillaris, suppress colorectal cancer by targeting the iron metabolism pathwayKai-Cheng Du, Guo-Chang Li, Yu-Hang Li, et al.
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