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Bioorganic Chemistry|May 1, 2026
Biosynthesis-guided classification of Hirsutane sesquiterpenoids and their structural diversificationMengjiao Guo, Chunlei Wang, Chengwei Liu
Bioorganic Chemistry|April 30, 2026
ATI-1 mediated disruption of the VCP-UFL1-Beclin1 axis thwarts autophagy initiation to trigger metabolic catastrophe in autophagy-addicted cancersTong Liu, Min Zhao, Jing Gao, et al.
Bioorganic Chemistry|April 28, 2026
Thieno[3,2-b]pyrrole-annulated BODIPYs: Charge-transfer-assisted intersystem crossing and NIR photosensitization for PDTD V Sobenin, J A Sutemieva
Bioorganic Chemistry|April 28, 2026
DA-5: A novel azaindole-based GPX4 inhibitor inducing ferroptosis for targeted therapy of triple-negative breast cancerJingjing Du, Kaiqiang Guo, ChaoJie Wang, et al.
Bioorganic Chemistry|April 14, 2026
Stapled anoplin with perfluoroaryl-cysteine enhances antibacterial activityShiting Chen, Jiawei Chen, Xun Xu, et al.
Bioorganic Chemistry|April 18, 2026
Phosphate-based 2,3-DPG mimetics as Hemoglobin allosteric modulators with potent anti-hypoxic activityChang Wang, Yingfei Zhang, Wanteng Yao, et al.
Bioorganic Chemistry|April 13, 2026
Benzalkonium chloride and its derivatives as 5α-reductase 1 inhibitors to disrupt neurosteroid biosynthesisYinghao Huang, Chentao Ding, Shaowei Wang, et al.
Bioorganic Chemistry|April 10, 2026
Discovery of the first-in-class highly potent FXR/HSD17B13 dual modulator for the treatment of metabolic dysfunction-associated steatohepatitisXue Xu, Yuxia Liu, Zhongcheng Yang, et al.
Bioorganic Chemistry|April 8, 2026
Discovery, engineering and application of a maleate isomerase for efficient L-malic acid biosynthesis via dual-enzyme cascade with fumaraseWenjing Huang, Ji Ding, Cheng Cheng, et al.
Bioorganic Chemistry|April 10, 2026
Prodigiosin inhibits proliferation and metastasis in head and neck squamous cell carcinoma: insights from phenotypic validation and network pharmacologyXinhui Mao, Huiying Huang, Limin Zhao, et al.
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