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Bioorganic Chemistry|May 7, 2026
Development of a novel near-infrared probe for butyrylcholinesterase accurate detection in vitro and in vivoShuaige Bai, Bin Feng, Qixing Dong, et al.
Bioorganic Chemistry|May 8, 2026
1,6-Val₂GalNAz: An efficient metabolic chemical reporter for O-linked glycan labeling with minimal S-glyco modificationZhiang Huang, Songshen Chu, Song Huang, et al.
Bioorganic Chemistry|May 8, 2026
Design, computational profiling, synthesis and biological evaluation of novel 1,2,4-triazole based derivatives as antioxidant and potent p53-MDM2 inhibitorsDushyant D Kotadiya, Pooja S Thakur, Ruchi Nair, et al.
Bioorganic Chemistry|May 17, 2026
Discovery of 4-((2S,5R)-2-((difluoromethoxy)methyl)-5-(4-(trifluoromethyl)phenyl)piperidin-1-yl)-N-((R)-1-(4-(ethylsulfonyl)phenyl)-2-hydroxyethyl)benzamide as a potent, orally available RORγt inverse agonistWei Cao, Bing Liu, Ning Kang, et al.
Bioorganic Chemistry|May 17, 2026
A target-directed platform for identification of ligands of Schistosoma mansoni methylthioadenosine phosphorylase in natural product extractsLucas G do Amaral, Miguel F S de Abreu, Renato C S Lessa, et al.
Bioorganic Chemistry|May 19, 2026
Development of dual A2AR/EGFR targeting pyrazoline-thiazole hybrids for restored apoptotic balance in colorectal cancerNoura Z Elzoghbi, Safaa M Kishk, Ashraf H Abadi, et al.
Bioorganic Chemistry|May 18, 2026
Synthesis and biological evaluation of mixed aryl-alkyl succinates as modulators of autophagy and apoptosis in gastric carcinomaDiego Olivieri, Michele Mari, Michela Battistelli, et al.
Bioorganic Chemistry|May 18, 2026
Discovery of selenium-containing amino acid derivatives as novel ENL YEATS domain inhibitors via AlphaScreen-based high throughput screeningSiqi Guo, Jianhao Li, Yongxing Tao, et al.
Bioorganic Chemistry|May 18, 2026
Discovery of novel IKKβ allosteric inhibitors as dual-antioxidant for cerebral ischemia-reperfusion injury therapy by upregulating HO-1 and SLC7A11Jianzhang Wu, Ge Li, Xiangpeng Tan, et al.
Bioorganic Chemistry|April 16, 2026
Unraveling the molecular interaction of hydroxytyrosol with human serum albumin via multi-spectroscopy, thermodynamic analysis, molecular docking and molecular dynamics simulationYan Xiong, Jilong Ma, Xiaocheng Zeng, et al.
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