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Bioorganic Chemistry|August 6, 2026
Novel 2-amino-4-(1H-imidazol)pyridine derivatives as potent brain-penetrant EGFR mutant inhibitors: Design, synthesis, biological evaluation, and molecular modeling studyTingting Zhang, Shunli Peng, Yaqi Huang, et al.
Bioorganic Chemistry|August 12, 2026
Development of novel diaryl ether-phenolic Mannich Base derivatives with potent cholinesterase inhibition and low neuronal toxicityHalil Şenol, Yeliz Demir, Pelin Tokalı, et al.
Bioorganic Chemistry|August 21, 2026
Discovery and characterization of pyridazino[4,5-b]indol-4-one derivatives as NaV1.8 inhibitors: A novel approach for targeting chronic painShilong Hu, Gen Li, Runduo Liu, et al.
Bioorganic Chemistry|August 21, 2026
Integrative drug repositioning identifies FDA-approved inhibitors of HSP90AA1 with therapeutic potential in colorectal cancerXuan Li, Shaofen Xu, Muhammad Waqas, et al.
Bioorganic Chemistry|August 18, 2026
Discovery of Aspxanthones A-I with SIRT1 agonist activity from Aspergillus sp. TJ507Xueqi Lan, Dongchun Liang, Li Tang, et al.
Bioorganic Chemistry|August 18, 2026
Design, synthesis, and biological evaluation of novel furo[3,2-b]pyrrole-benzimidazole series as potential protein tyrosine phosphatase (PTPs) inhibitorsSlieman Milaneh, Zehao Ye, Li-Xing Gao, et al.
Bioorganic Chemistry|August 18, 2026
Benzo[h]quinoline-based heterocyclic derivatives as Culex pipiens larvicidal candidates: synthesis, bioactivity, biochemical response, and in silico mechanistic insightsEman A E El-Helw, Mahmoud Kamal, Eslam M Hosni, et al.
Bioorganic Chemistry|August 18, 2026
Activity cliffs resist prediction within and across protein kinases: a leakage-controlled machine-learning analysis of structure-potency discontinuitiesSamuel S Agboola, Oluwaseun E Agboola, Oluwaseun Ruth Olasehinde, et al.
Bioorganic Chemistry|August 18, 2026
Development of thiazole-hydrazone hybrids for targeted therapy of non-small cell lung cancerMehlika Dilek Altıntop, İpek Ertorun, Gülşen Akalın Çiftçi, et al.
Bioorganic Chemistry|August 14, 2026
Indole-thiazole derivatives as schistosomicidal agents against Schistosoma mansoni: synthesis, in vitro and in vivo efficacy, immunomodulation, and in silico interaction with cathepsin B1Lisandra da Silva Lima, Maria Emanuelle de Oliveira Queirós, Diego Santa Clara Marques, et al.
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