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Bioorganic Chemistry|September 21, 2026
Discovery of cyanocarbonimidodithioates as novel non-hydroxamate zinc-binding groups for selective HDAC8 inhibition: Design, synthesis, biological evaluation, anticancer activity, and in silico studiesSai Chaitanya Kosana, Hrushikesh Chaudhari, Ashna Fathima, et al.
Bioorganic Chemistry|September 26, 2026
Oleanolic acid-selenocyanate hybrids trigger replication-associated DNA damage responses and suppress tumour growth in vitro and in vivoRosa I Martínez-Lara, Aday González-Bakker, Adam N Khan, et al.
Bioorganic Chemistry|September 26, 2026
Rationale design and synthesis of new quinazoline derivatives as DNA intercalators and topoisomerase II inhibitorsAmr Helmy, Mamdouh F A Mohamed, Ibrahim H Eissa, et al.
Bioorganic Chemistry|October 1, 2026
Redox-active Selenoglycoconjugates: Synthetic strategies, biological evaluation, and preliminary insights from mannose-derived analoguesClaudia González, Giovanna Cimmino, Lara Comune, et al.
Bioorganic Chemistry|October 1, 2026
Quality by design-assisted development of an intranasal Shikonin-loaded Mucoadhesive microemulsion for enhanced brain delivery: optimization, characterization, and Pharmacodynamic evaluation in a schizophrenia modelPavan Kumar Inuganti, Kumaraswamy Gandla, Lalitha Repudi, et al.
Bioorganic Chemistry|September 29, 2026
Computational framework-guided engineering of microbial transglutaminase enables site-specific conjugation of TrastuzumabKanghui Yu, Zhe Wang, Xinxin Chen, et al.
Bioorganic Chemistry|September 30, 2026
Unveiling cytotoxicity and antimicrobial potential of novel N-(2-((5-aryl-quinolin-8-yl)oxy)ethyl)sulfonamide derivatives: synthesis, cytotoxicity, antimicrobial, QSAR based anti-cancer evaluation and in silico studiesSunil Sonawane, Mohd Shahbaaz, Pravin C Mhaske, et al.
Bioorganic Chemistry|September 30, 2026
Identification of CD40 as the target of artemisinin via targeted degradomics for ulcerative colitisZhiqi Zhang, Haoze Song, Yixing Li, et al.
Bioorganic Chemistry|September 25, 2026
Tryptophan substitutions reveal cooperative membrane transitions and aromatic interactions associated with membrane permeabilisation in CM15 and MSI-78 peptide analoguesMatías Zapata-Lizama, Yesseny Vásquez-Martínez, Patricio Briones-Rebolledo, et al.
Bioorganic Chemistry|September 27, 2026
Design, synthesis, mechanistic evaluation, and in silico study of pyrimidine-coumarin hybrids as promising anticancer agentsR Vinay, Shankar G Alegaon, H S Basavaraja, et al.
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