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CPT: Pharmacometrics & Systems Pharmacology|November 16, 2023
Realizing the promise of Project Optimus: Challenges and emerging opportunities for dose optimization in oncology drug developmentWei Gao, Jiang Liu, Blerta Shtylla, et al.CPT: Pharmacometrics & Systems Pharmacology|November 15, 2023
A model-based approach leveraging in vitro data to support dose selection from the outset: A framework for bispecific antibodies in immuno-oncologyJavier Sánchez, Christina Claus, Rosmarie Albrecht, et al.CPT: Pharmacometrics & Systems Pharmacology|September 1, 2023
Mid-dosing interval concentration is important for polymyxin B exposure and acute kidney injury in critically ill patientsJing Wang, Yuanchen Li, Siqi Huang, et al.CPT: Pharmacometrics & Systems Pharmacology|August 10, 2023
Semimechanistic pharmacokinetic-pharmacodynamic model of tripegfilgrastim for pediatric patients after chemotherapySoyoung Lee, Kyung Taek Hong, In-Jin Jang, et al.CPT: Pharmacometrics & Systems Pharmacology|August 8, 2023
Item response theory in early phase clinical trials: Utilization of a reference model to analyze the Montgomery-Åsberg Depression Rating ScaleMarije E Otto, Kirsten R Bergmann, Marieke L de Kam, et al.CPT: Pharmacometrics & Systems Pharmacology|August 3, 2023
SARS-CoV-2 viral dynamic modeling to inform model selection and timing and efficacy of antiviral therapyShengyuan Zhang, Akosua A Agyeman, Christoforos Hadjichrysanthou, et al.CPT: Pharmacometrics & Systems Pharmacology|August 24, 2023
A comprehensive evaluation in clinic and physiologically-based pharmacokinetic modeling and simulation to confirm lack of cytochrome P450-mediated drug-drug interaction potential for pomotrelvirZiping Yang, Nathalie Rioux, Ludwig Vincent, et al.CPT: Pharmacometrics & Systems Pharmacology|August 19, 2023
Population pharmacokinetic analyses for belzutifan to inform dosing considerations and labelingDhananjay D Marathe, Petra M Jauslin, Huub Jan Kleijn, et al.CPT: Pharmacometrics & Systems Pharmacology|October 14, 2023
Toward improved predictions of pharmacokinetics of transported drugs in hepatic impairment: Insights from the extended clearance modelFlavia Storelli, Mayur K Ladumor, Xiaomin Liang, et al.CPT: Pharmacometrics & Systems Pharmacology|October 20, 2023
A multistate platform model for time-to-event endpoints in oncology clinical trialsChih-Wei Lin, Mario Nagase, Sameer Doshi, et al.Pageof 152