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Drug Development Research|March 30, 2026
Design and Synthesis of Bis-3,4-Dimethoxybenzene-Fibrate Derivatives as Potential Lipid-Lowering and Hepatoprotective Agents Based on the Principles of Structural Simplification and BioisosterismLing Ding, Yuyu An, Huizi Shangguan, et al.
Drug Development Research|April 1, 2026
Unlocking the Anticancer Potential of New Spirooxindoles via p53-MDM2/MDMX Dual Inhibition: In Vitro and In Silico AssessmentsHaidy H El-Zoheiry, Rehab F Ahmed, Mahmoud S Elkotamy, et al.
Drug Development Research|April 27, 2026
DPP4-Driven Ferroptosis Promotes Senescence: Galangin as a Therapeutic Agent for Age-Related Bone LossHongming Zhou, Xiaoxi Liu, Hengren Li, et al.
Drug Development Research|May 12, 2026
Pyrimidine-Derived Scaffolds Targeting VEGFR-2, EGFR, and HER-2: Synthesis, Anticancer/Immunomodulatory Evaluation, and In Silico AnalysisNaglaa M Ahmed, Mohamed S Gaballah, Belen Altava, et al.
Drug Development Research|May 11, 2026
Exploring the Role of Novel N (4) Substituted 5,7-Dibromoisatin Thiosemicarbazones in Modulating PTOV1 Activity for Therapeutic Relevance in Breast CancerPiyush Kumar, Upendra Chaudhary, Kuldeep Mahiya, et al.
Drug Development Research|April 20, 2026
PKCδ-Drp1 Axis Mediates VIP-Induced Mitochondrial Fragmentation and Metabolic Crisis in Nasopharyngeal CarcinomaJingda Xu, Guanzheng Wu, Min Chen, et al.
Drug Development Research|April 27, 2026
Secoisolariciresinol Diglucoside Alleviates LPS-Induced Acute Lung Injury by Inhibiting the NF-κB/NLRP3 Signaling PathwayYuanyuan Zhong, Yang Zou, Zhen Qu, et al.
Drug Development Research|April 27, 2026
Discovery of Tetrahydropyrrolo[3,4-c]pyrrole-1,3-dione Derivatives as Novel RIPK1 Inhibitors via Pharmacophore-Based Virtual ScreeningXin Zeng, Yanzhen Yu, Yifan Wu, et al.
Drug Development Research|April 28, 2026
Sustained DNA Hypomethylation Induced by a DNA Methyltransferase 1 Inhibitor Triggers Apoptosis in Thyroid Cancer CellsChao-Wen Cheng, Wen-Fang Fang, Yuan-Hung Wang, et al.
Drug Development Research|March 29, 2026
PTC-Assisted Chemoselective S-Alkylation of 5-Mercapto-1,3,4-Oxadiazol Derivative: Multi-Target Anticancer via EGFR, Telomerase, and Thymidylate Synthase Inhibition With Apoptosis InductionAsmaa Zakaria, Ahmed A Al-Karmalawy, Samia S Hawas, et al.
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