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European Journal of Medicinal Chemistry|February 13, 2025
From Dyrk1A inhibitors to a novel class of antiviral agents: Targeting Enterovirus EV-A71 with 2-aryl-substituted thiophene scaffoldsParthiena M Keddis, Tuong-Khanh My Tu, Hugo Scherer, et al.
European Journal of Medicinal Chemistry|February 5, 2025
Recent advances in small molecule inhibitors of deubiquitinating enzymesPengwei Liu, Zhengyang Chen, Yiting Guo, et al.
European Journal of Medicinal Chemistry|February 5, 2025
Design and synthesis of novel sulfur-substituted triptolide with the ability to induce autophagy through inhibition of SRSF1 expressionXinyi Chen, Jichen Guan, Yuzhi Lin, et al.
European Journal of Medicinal Chemistry|March 4, 2025
Discovery of a potent and in vivo anti-inflammatory Efficacious, P2Y14R antagonist with a novel benzisoxazoles scaffold by DNA-encoded chemical library technologyZhiyi Wei, Bingqian Han, Longhua Yang, et al.
European Journal of Medicinal Chemistry|February 5, 2025
Hit to lead optimization of the 4-trifluoromethylquinoline derivatives as novel SGK1 inhibitors with potent anti-prostate cancer activityCheng Li, Sha Cheng, Jia Yu, et al.
European Journal of Medicinal Chemistry|February 5, 2025
Design, synthesis and evaluation of diarylidenyl piperidone-ligated platinum (IV) complexes as chemoimmunotherapeutic agentsZhi-Chen Mao, Lei Chen, Xiao-Man Chen, et al.
European Journal of Medicinal Chemistry|January 26, 2025
Rationally designed highly amphipathic antimicrobial peptides demonstrating superior bacterial selectivity relative to the corresponding α-helix peptideJingying Zhang, Anqi Chu, Xu Ouyang, et al.
European Journal of Medicinal Chemistry|February 1, 2025
Discovery and preclinical evaluations of drug candidate DA-0157 capable of overcoming EGFR drug-resistant mutation C797S and EGFR/ALK co-mutationsPeng He, Haiyan Li, Zhenyu Yang, et al.
European Journal of Medicinal Chemistry|February 18, 2025
Discovery of β-amino acid substituted naphthalene sulfonamide derivatives as potent Kelch-like ECH-associated protein 1-nuclear factor erythroid 2-related factor 2 (Keap1-Nrf2) protein-protein interaction inhibitors for ulcerative colitis managementZiquan Zhao, Hongjin Lu, Junjie Wang, et al.
European Journal of Medicinal Chemistry|February 1, 2025
Rational design of dual-agonist peptides targeting GLP-1 and NPY2 receptors for regulating glucose homeostasis and body weight with minimal nausea and emesisJing Liu, Weiwen Lu, Han Wu, et al.
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