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European Journal of Medicinal Chemistry|December 11, 2024
Design, synthesis and biological evaluation of novel diaryl-substituted fused nitrogen heterocycles as tubulin polymerization inhibitors to overcome multidrug resistance in vitro and in vivoFuhao Jiang, Min Yu, Yang Wang
European Journal of Medicinal Chemistry|December 21, 2024
Chemical dissection of selective myeloid leukemia-1 inhibitors: How they were found and evolvedLuyao Wang, Yuxiang Chen, Maoqian Zhang, et al.
European Journal of Medicinal Chemistry|December 10, 2024
Synthesis of novel deuterated EGFR/ALK dual-target inhibitors and their activity against non-small cell lung cancerHaoran Nie, Shuai Zhang, Lihan Wang, et al.
European Journal of Medicinal Chemistry|December 14, 2024
Triterpenoid phthalimides as selective anti-cancer agents targeting mitochondrial apoptosisAnna Kazakova, Ivo Frydrych, Nikola Jakubcová, et al.
European Journal of Medicinal Chemistry|November 14, 2024
Structural insights into tryptamine psychedelics: The role of hydroxyl indole ring site in 5-HT2A receptor activation and psychedelic-like activityMiyuan Zhang, Yuefeng Yang, Zhishuai Yang, et al.
European Journal of Medicinal Chemistry|November 16, 2024
Synthesis and evaluation of a novel BODIPY fluorescent probe targeting integrin αvβ3 for cancer diagnosisBin Rong, Xiaochun Dong, Weili Zhao
European Journal of Medicinal Chemistry|November 20, 2024
Discovery of a novel, selective CK2 inhibitor class with an unusual basic scaffoldHend Khalifa, Ahmed K ElHady, Ting Liu, et al.
European Journal of Medicinal Chemistry|November 19, 2024
Optimisation of a novel series of ENaC inhibitors, leading to the selection of the long-acting inhaled clinical candidate ETD001, a potential new treatment for cystic fibrosisHenry Danahay, Martin Gosling, Roy Fox, et al.
European Journal of Medicinal Chemistry|November 19, 2024
Design, synthesis and anti-tumor evaluation of novel pyrimidine and quinazoline analoguesRen-Jie Lin, Lin Xie, Tian-Yu Gao, et al.
European Journal of Medicinal Chemistry|November 24, 2024
Novel potent SOS1 inhibitors containing a tricyclic quinazoline scaffold: A joint view of experiments and simulationsLuolong Qing, Zhengzai Cheng, Juan Xu, et al.
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