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European Journal of Medicinal Chemistry|October 11, 2025
DNMT1 drives glioma progression and modulates therapy response: A novel therapeutic targetAlkinoos A Armoundas, Christina Piperi
European Journal of Medicinal Chemistry|October 7, 2025
Design, synthesis and biological evaluation of 8-phenylquinazolin-2-amine derivatives as FLT3 covalent inhibitors targeting cysteine 828 in the ATP pocketWei Wei, Zuli Hu, Jiuyu Gao, et al.
European Journal of Medicinal Chemistry|October 5, 2025
QS-21: Structural insights, immunological mechanisms, and prospects for rational design of safer vaccine adjuvantsYanmei Hu, Yuyang Wu, Haicui Liu, et al.
European Journal of Medicinal Chemistry|October 4, 2025
Discovery of Y502-2304, a potent c-Myc G-quadruplex stabilizer for the treatment of multiple myelomaJian Gao, Xinxin Qu, Mengting Li, et al.
European Journal of Medicinal Chemistry|October 10, 2025
Identification of a novel benzyloxy-terminated scaffold as a potent and selective TYK2 inhibitor for anti-inflammatory therapyYang Tian, Yanzhuo Liu, Jianyu Liu, et al.
European Journal of Medicinal Chemistry|October 10, 2025
A double-edged sword of neo-substrate degradation in PROTACsZihan Song, Chengze Duan, Mingfei Wu, et al.
European Journal of Medicinal Chemistry|September 28, 2025
Discovery and validation of LAGi-DEL: A nanomolar LAG-3 inhibitor that reverses immune suppression in tumor-immune co-culture modelsHossam Nada, Laura Calvo-Barreiro, Somaya A Abdel-Rahman, et al.
European Journal of Medicinal Chemistry|September 28, 2025
Quinazoline-based dual-target inhibitors disrupt influenza virus RNP complex: Rational design, synthesis and mechanistic validation of potent anti-influenza agentsChao Zhang, Xu-Hui Huang, Zhe Wang, et al.
European Journal of Medicinal Chemistry|September 30, 2025
Discovery of novel potent indazole-based FXR agonists via scaffold hopping for MASH treatmentDa-Yu Shi, Xin-Wei Shi, Hang Shi, et al.
European Journal of Medicinal Chemistry|September 30, 2025
Locally constrained xylene-based cyclic mimetics of SOCS3 proteinAlessia Cugudda, Sara La Manna, Francesco Cozzolino, et al.
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